TARGAPREMIR-210
| 中文名称 | TARGAPREMIR-210 |
|---|---|
| 中文同义词 | 化合物 T16991 |
| 英文名称 | ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]- |
| 英文同义词 | ButanaMide, N-(3-azidopropyl)-4-[3-[6-(4-Methyl-1-piperazinyl)[2,6'-bi-1H-benziMidazol]-2'-yl]phenoxy]-;N-(3-azidopropyl)-4-[3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenoxy]butanamide;Targapremir-210;N-(3-azidopropyl)-4-(4-(6-(4-methylpiperazin-1-yl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenoxy)butanamide;Targapremir-210 (TGP-210);Targapremir 210,Targapremir210 |
| CAS号 | 1049722-30-6 |
| 分子式 | C32H36N10O2 |
| 分子量 | 592.71 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1049722-30-6.mol |
| 结构式 |  |
TARGAPREMIR-210 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：250 mg/mL（421.81 mM） |
Targapremir-210 (TGP-210) 是一种有效的、选择性的 miR-210 抑制剂。 Targapremir-210 以高亲和力抑制 pre-miR-210 的加工 (Kd~200 nM)。
IC50: 200 nM (miR-210, in MDA-MB-231 cells).
Targapremir-210 decreases mature miR-210 levels in MDA-MB-231 cells cultured under hypoxic conditions, with an IC
50
of ∼200 nM.
Targapremir-210 (200 nM) induces MDA-MB-231 cells apoptosis is selective for the hypoxic environment. Targapremir-210 induces cells apoptosis under hypoxic conditions and does not induce apoptosis in MDA-MB-231 cells cultured in normoxia.
Targapremir-210 (100 μL of 200 nM; single i.p. injection) impedes MDA-MB-231 triple negative breast cancer (TNBC) cells proliferation in vivo. Targapremir-210 is able to reach the tumor and sustain for the entire 21-day period, and decreases tumor burden in a TNBC mouse model.
| Animal Model: | NOD/SCID mice were subcutaneously transplanted cell suspension into breast fat pads. |
| Dosage: | 100 μL of 200 nM |
| Administration: | Single i.p. injection 24 h post-transplantation |
| Result: | Decreased tumor growth as assessed by luciferase signal intensity and mass of the resected tumor. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15861 | Targapremir-210 | 1 mg | 2045元 | |
| 2024/04/30 | HY-15861 | TARGAPREMIR-210 Targapremir-210 | 1049722-30-6 | 5mg | 4500元 |