192718-06-2
中文名称 | 192718-06-2 |
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中文同义词 | 2-(4-氟苯基)萘并[2,3-D]恶唑-4,9-二酮;化合物C527 |
英文名称 | 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione |
英文同义词 | 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;C527;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;C527 >=98% (HPLC);Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit;2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione |
CAS号 | 192718-06-2 |
分子式 | C17H8FNO3 |
分子量 | 293.25 |
EINECS号 | |
相关类别 | 药品 |
Mol文件 | 192718-06-2.mol |
结构式 |
192718-06-2 性质
沸点 | 488.6±47.0 °C(Predicted) |
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密度 | 1.433±0.06 g/cm3(Predicted) |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 在DMSO中的溶解度为0.3mg/mL,澄清(加热) |
酸度系数(pKa) | -4.21±0.20(Predicted) |
形态 | 粉末 |
颜色 | 淡黄色至深黄色 |
0.88 μM (USP1)
Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-12988 | C527 | 1 mg | 240元 | |
2024/08/19 | HY-12988 | 192718-06-2 C527 | 192718-06-2 | 5mg | 600元 |