PD089828
| 中文名称 | PD089828 |
|---|---|
| 中文同义词 | N-[2-氨基-6-(2,6-二氯苯基)吡啶基[2,3-d]嘧啶-7-基]-N'-叔丁基脲;1-(2-氨基-6-(2,6-二氯苯基)吡啶并[2,3-D]嘧啶-7-基)-3-叔丁基脲;化合物PD 089828 |
| 英文名称 | PD089828 |
| 英文同义词 | PD089828;1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea;Urea, N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-;EGFR,ATP,nonselective,PD 089828,PDGFR,autophosphorylation,PD089828,HER1,Epidermal growth factor receptor,ErbB-1,phosphorylation,vascular,antiproliferative,smooth,antimigratory,competitive,Inhibitor,Platelet-derived growth factor receptor,PD-089828,Src,muscle,cells,FGFR,inhibit,Fibroblast growth factor receptor |
| CAS号 | 179343-17-0 |
| 分子式 | C18H18Cl2N6O |
| 分子量 | 405.28 |
| EINECS号 | |
| 相关类别 | 化工 |
| Mol文件 | 179343-17-0.mol |
| 结构式 |  |
PD089828 性质
| 密度 | 1.416±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：25mg/mL；乙醇：1mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 9.85±0.43(Predicted) |
|
FGFR1 0.15 μM (IC 50 ) |
PDGFR-β 1.76 μM (IC 50 ) |
EGFR 5.47 μM (IC 50 ) |
c-Src 0.18 μM (IC 50 ) |
FGFR1 0.14 μM (Ki) |
PDGFR-β 2.38 μM (Ki) |
EGFR 3.16 μM (Ki) |
c-Src 0.1 μM (Ki) |
PD-089828 (0.5-20 µM; 2 hours) inhibits PDGFR autophosphorylation with an IC
50
of 0.82 µM.
PD-089828 (1-50 µM; 2 hours) inhibits EGFR autophosphorylation with an IC
50
value of 10.9 µM.
In A121(p) cells, PD 089828 potently inhibits the phosphorylation of FGFR-1 with an IC
50
value of 0.63 µM.
PD-089828 (10 µM; 8 days) produces a concentration-related inhibition of serum-stimulated cell growth with an IC
50
value of 1.8 µM.
PD-089828 inhibits increases in DNA synthesis stimulated by all three growth factors, with IC
50
values of 0.8 for PDGF-, 1.7 for EGF- and 0.48 µM for bFGF-induced mitogenesis.
Cell Proliferation Assay
| Cell Line: | Vascular smooth muscle cells (serum-stimulated growth) |
| Concentration: | 10 µM |
| Incubation Time: | 8 consecutive days |
| Result: | Produced a concentration-related inhibition of serum-stimulated cell growth with an IC50 value of 1.8 µM. |
Western Blot Analysis
| Cell Line: | Vascular smooth muscle cells (stimulated with PDGF-BB 30 ng/ml) |
| Concentration: | 0.5-20 µM |
| Incubation Time: | 2 hours |
| Result: | Inhibited PDGFR autophosphorylation with an IC 50 of 0.82 µM. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-112345 | PD-089828 | 1 mg | 360元 | |
| 2024/04/30 | HY-112345 | PD089828 PD-089828 | 179343-17-0 | 5 mg | 900元 |