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Product Name:Chlamydocin
CAS:53342-16-8
Purity:95% Remarks:Chlamydocin is produced by the strain of Diheterospora chlamydosporia. The inhibitory activity of mo
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| | CHLAMYDOCIN Basic information |
| Product Name: | CHLAMYDOCIN | | Synonyms: | Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl];CHLAMYDOCIN;2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-];Antibiotic SL-3440;SL-3440;Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl] | | CAS: | 53342-16-8 | | MF: | C28H38N4O6 | | MW: | 526.63 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 53342-16-8.mol |  |
| | CHLAMYDOCIN Chemical Properties |
| Boiling point | 861.8±65.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid | | pka | 13.36±0.70(Predicted) |
| | CHLAMYDOCIN Usage And Synthesis |
| Description | Chlamydocin is a histone deacetylase (HDAC) inhibitor that was originally isolated from D. chlamydosporia and has anticancer properties. It is selective for HDAC1 over HDAC6 (IC50 = 0.15 and 1,100 nM, respectively). Chlamydocin increases acetylation of histone H3 and histone H4 in A2780 cells when used at concentrations ranging from 1 to 1,000 nM. It inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively). Chlamydocin increases lifespan by 10% in a P185 mouse allograft model when administered at doses ranging from 20 to 160 mg/kg. | | Uses | Chlamydocin is a cyclic tetrapeptide and an irreversible histone deacetylase (HDAC) inhibitor. |
| | CHLAMYDOCIN Preparation Products And Raw materials |
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