UNC3230
| 中文名称 | UNC3230 |
|---|---|
| 中文同义词 | 5-(环己烷甲酰胺基)-2-(苯基氨基)噻唑-4-甲酰胺;化合物UNC 3230;UNC 3230,PIP5K1C抑制剂 |
| 英文名称 | UNC3230 |
| 英文同义词 | UNC3230;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor |
| CAS号 | 1031602-63-7 |
| 分子式 | C17H20N4O2S |
| 分子量 | 344.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1031602-63-7.mol |
| 结构式 |  |
UNC3230 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO:30.0(最大浓度 mg/mL);87.1(最大浓度 mM) DMF:30.0(最大浓度 mg/mL);87.1(最大浓度 mM) 乙醇:0.2(最大浓度 mg/mL);0.58(最大浓度 mM) |
| 形态 | 结晶固体 |
IC50: ~41 nM (Phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C))
Membrane PIP2 levels are significantly reduced by ~45% in dorsal root ganglia (DRG) neurons treated with 100 nM UNC3230 (~2-fold above the IC50) relative to vehicle controls. UNC3230 significantly reduces lysophosphatidic acid (LPA)-evoked calcium signaling in cultured DRG neurons relative to vehicle.
UNC3230 (2 nmol) significantly increases noxious heat-evoked paw withdrawal latency for two hours after intrathecal injection in wild-type mice, indicating an antinociceptive effect.
UNC3230 (2 nmol; intrathecal injection) is administered then one hour later co-injected 1 nmol LPA with UNC3230 (2 nmol, intrathecal injection). UNC3230 significantly blunts thermal hyperalgesia and mechanical allodynia compared to vehicle.
UNC3230 (2 nmol; intrathecal injection) significantly blunts thermal hyperalgesia and mechanical allodynia in the complete Freund’s adjuvant (CFA)-inflamed hindpaw (relative to vehicle control) but does not affect thermal or mechanical sensitivity in the control (non-inflamed) hindpaw over a multiday time course.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110150 | UNC3230 | 1 mg | 590元 | |
| 2024/04/30 | HY-110150 | UNC3230 UNC3230 | 1031602-63-7 | 5mg | 1300元 |