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Sichuan BioCrick Biotech Co., Ltd Gold
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Product Name:Ailanthoidol
CAS:156398-61-7
Purity:98% HPLC Package:5mg;10mg;20mg;50mg……1g
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| Company Name: |
BioBioPha Co., Ltd.
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0871-65217109 13211707573; |
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| Products Intro: |
Product Name:Ailanthoidol
CAS:156398-61-7
Purity:97.5% Package:5mg Remarks:BBP04946
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903 |
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3008007409@qq.com |
| Products Intro: |
Product Name:Ailanthoidol
CAS:156398-61-7
Purity:HPLC≥97.5% Package:5mg
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| Company Name: |
Shanghai Bohu Biotechnology Co., LTD
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021-57763112 13585886131 |
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3004987436@qq.com |
| Products Intro: |
Product Name:Ailanthoidol
CAS:156398-61-7
Purity:97.5% Package:100g/
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| | Ailanthoidol Basic information |
| Product Name: | Ailanthoidol | | Synonyms: | Ailanthoidol;Phenol, 4-[5-[(1E)-3-hydroxy-1-propen-1-yl]-7-methoxy-2-benzofuranyl]-2-methoxy- | | CAS: | 156398-61-7 | | MF: | C19H18O5 | | MW: | 326.34 | | EINECS: | | | Product Categories: | | | Mol File: | 156398-61-7.mol |  |
| | Ailanthoidol Chemical Properties |
| Melting point | 199-201 °C | | Boiling point | 539.2±45.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | pka | 9.31±0.20(Predicted) | | InChI | InChI=1S/C19H18O5/c1-22-17-10-13(5-6-15(17)21)16-11-14-8-12(4-3-7-20)9-18(23-2)19(14)24-16/h3-6,8-11,20-21H,7H2,1-2H3/b4-3+ | | InChIKey | ZDQCRQVGMKIBPN-ONEGZZNKSA-N | | SMILES | C1(O)=CC=C(C2=CC3=CC(/C=C/CO)=CC(OC)=C3O2)C=C1OC |
| | Ailanthoidol Usage And Synthesis |
| Uses | Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion[1][2]. | | in vivo | Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO[1].
| Animal Model: | Eight-week-old male BALB/c mice[1] | | Dosage: | 0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg | | Administration: | Oral gavage, 24 hours and 1 hours before LPS was injected, for 5 days | | Result: | Significantly improved the mortality of these mice in a concentration-dependent manner and no mice were killed in the 20mg/kg group. |
| | References | [1] Jin-Kyung Kim, et al. Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Cell Biochem. 2011 Dec;112(12):3816-23. DOI:10.1002/jcb.23312
[2] Yean-Jang Lee, et al. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol Rep. 2006 Oct;16(4):921-7. PMID:16969515 |
| | Ailanthoidol Preparation Products And Raw materials |
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