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ZM 336372

ZM 336372 更多供应商
公司名称: 上海波以尔化工有限公司  
联系电话:
产品介绍: 英文名称:ZM 336372
CAS:208260-29-1
公司名称: 北京百灵威科技有限公司  
联系电话: 400-666-7788 010-82848833
产品介绍: 英文名称:ZM 336372
CAS:208260-29-1
包装信息:2.5g,250Mg 备注:化学试剂、精细化学品、医药中间体、材料中间体
公司名称: 武汉易泰科技有限公司上海分公司  
联系电话: 18930552037 821-50328103-801
产品介绍: 英文名称:ZM 336372;3-(DiMethylaMino)-N-[3-[(4-hydroxybenzoyl)-aMino]-4-Methylphenyl]benzaMide
CAS:208260-29-1
纯度:99% HPLC 包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
公司名称: 上海佰世凯化学科技有限公司  
联系电话: 021-20908456
产品介绍: 英文名称:ZM 336372
CAS:208260-29-1
备注:C14484
公司名称: 上海源鼎化学科技有限公司  
联系电话: 21-57721279
产品介绍: 英文名称:3-(dimethylamino)-N-(3-(4-hydroxybenzamido)-4-methylphenyl)benzamide
CAS:208260-29-1
纯度:97% or 98% 包装信息:1g,5g,10g,25g,100g,1kg
最新发布供应信息
c-Raf抑制剂(ZM 336372)_上海泽叶生物科技有限公司
2021/7/21 19:28:01
ZM 336372_南京百鑫德诺生物科技有限公司
2020/3/30 13:12:37
ZM 336372
生物活性体外研究生物活性靶点体外研究 MSDS 用途与合成方法 ZM 336372价格(试剂级) 上下游产品信息
中文名称:ZM 336372
中文同义词:3-(二甲基氨基)-N-[3-[(4-羟基苯甲酰基)氨基]-4-甲基苯基]苯甲酰胺;C-RAF抑制剂(ZM 336372)
英文名称:ZM 336372
英文同义词:N-[5-(3-DIMETHYLAMINOBENZAMIDO)-2-METHYLPHENYL]-4-HYDROXYBENZAMIDE;ZM 336372;Zinc00581684;3-(DIMETHYLAMINO)-N-[3-[(4-HYDROXYBENZOYL)-AMINO]-4-METHYLPHENYL]BENZAMIDE;3-(diMethylaMino)-N-(3-(4-hydroxybenzaMido)-4-Methylphenyl)benzaMide;Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-;ZM 336372 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide;ZM 336372, >=98%
CAS号:208260-29-1
分子式:C23H23N3O3
分子量:389.45
EINECS号:
相关类别:小分子抑制剂;小分子抑制剂,天然产物;细胞生物学试剂;Inhibitors;MAPK;A potent and specific inhibitor of the protein kinase c-Raf.;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件:208260-29-1.mol
ZM 336372
ZM 336372 性质
沸点 484.4±45.0 °C(Predicted)
密度 1.298
储存条件 -20°C
溶解度 DMSO: >5mg/mL (warmed)
形态powder
酸度系数(pKa)8.31±0.15(Predicted)
颜色white to beige
敏感性 Light Sensitive
ZM 336372 用途与合成方法
生物活性ZM 336372是一种有效的,选择性的c-Raf抑制剂,IC50为70 nM,比作用于B-RAF选择性高10倍,对PKA/B/C, AMPK, p70S6等没有抑制作用。
体外研究ZM 336372 shows 10-fold selectivity over B-Raf. ZM 336372 weakly inhibits SAPK2a/p38α and SAPK2b/p38β with IC50 of 2 μM, and is selective over 17 other protein kinases including PKA, PKC, AMPK, p42 MAPK, MKK1, SAPK1/JNK, and CDK1 even at the concentration of up to 50 μM. ZM 336372 does not prevent constitutive as well as growth factor or phorbol ester induced activation of MKKl or p42 MAPK/ERK2. Moreover, ZM 336372 dose not reverse the phenotype of Ras- or Raf-transformed cell lines. ZM 336372 treatment induces >100 activation of c-Raf and the B-Raf isoform, but it does not trigger any activation of MKKI or p42 MAPK/ERKP or induce any increase in the GTP-loading of Ras, suggesting that a feedback control loop exists by which Raf isoforms suppress their own activation, such that inhibition is always counterbalanced by reactivation. ZM 336372-induced activation of c-Raf is not prevented by inhibition of the MAPK cascade, protein kinase C or phosphatidylinositide 3-kinase. ZM 336372 (1 μM) abolishes the upregulation of eNOS after treatment with hydrogen peroxide. ZM 336372 treatment in carcinoid tumor cells results in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2, and causes a significant reduction of bioactive hormone levels as well as the transcription factor, human achaete-scute homologue-1. Furthermore, ZM 336372 treatment leads to a marked suppression of cellular proliferation and induction of the cell cycle inhibitors p21 and p18. ZM 336372 inhibits the proliferation of pheochromocytoma cells, and suppresses NE vasoactive peptide production. ZM 336372 treatment in HepG2 induces the suppression of proliferation in a dose-dependent manner, suppression of hormone secretion, and up-regulation of cell cycle inhibitors. ZM 336372 also induces apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β through phosphorylation of GSK-3β at Ser 9.
生物活性ZM 336372 (Zinc00581684) 是一种有效的,选择性的c-Raf抑制剂,IC50为70 nM,比作用于B-RAF选择性高10倍,对PKA/B/C, AMPK, p70S6等没有抑制作用。
靶点
TargetValue
C-Raf 70 nM
体外研究

ZM 336372作用于C-Raf 的选择性是作用于B-Raf的10倍。ZM 336372微弱抑制SAPK2a/p38α和SAPK2b/p38β,IC50 为2 μM,即使在高达50 μM浓度下,对C-Raf的选择性也高于包括PKA,PKC,AMPK,p42 MAPK,MKK1,SAPK1/JNK,和CDK1等17种其他蛋白激酶。ZM 336372不会阻止生长因子或佛波酯诱导的MKKl或p42 MAPK/ERK2激活。此外,ZM 336372不会逆转Ras- 或Raf-转化细胞系的表现型。ZM 336372治疗诱导>100的c-Raf 和B-Raf亚型激活,但是它不会引起MKKI或p42 MAPK/ERKP激活,也不会诱导负载GTP的Ras增加,表明反馈控制环路通过Raf亚型抑制它们自身激活而存在,因此抑制作用总是被再活化而抵消。ZM 336372诱导的c-Raf活化不被MAPK级联激活,蛋白激酶C或磷脂酰肌醇3-激酶的抑制所阻断。ZM 336372 (1 μM)消除过氧化氢处理后eNOS的上调。 ZM 336372治疗,在良性肿瘤细胞中导致Raf-1,促分裂原活化蛋白激酶1/2,和细胞外信号调节激酶1/2连续磷酸化,并引起生物活性的激素水平,转录因子,和人无刚毛鳞甲同系物-1显著减少。此外,ZM 336372治疗显著抑制细胞增殖,并诱导细胞周期抑制剂p21和p18。 ZM 336372抑制嗜铬细胞瘤细胞的增殖,并抑制NE血管活性肽产生。 ZM 336372治疗,在HepG2中诱导剂量依赖性增殖抑制,激素分泌抑制,并上调细胞周期抑制剂。 在胰腺癌细胞系中,ZM 336372也会通过Ser 9上GSK-3β的磷酸化作用抑制糖原合成酶激酶-3β,从而诱导细胞凋亡。

安全信息
WGK Germany 3
ZM 336372 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2021/06/02S2720ZM 336372208260-29-15mg573.29元
2021/06/02S2720ZM 336372208260-29-110mg1056.39元
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