ARL 67156
中文名称 | ARL 67156 |
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中文同义词 | 化合物 T14320 |
英文名称 | ARL 67156 |
英文同义词 | ARL67156 trisodium salt,ARL-67156 trisodium salt |
CAS号 | 1021868-83-6 |
分子式 | C15H25Br2N5NaO12P3 |
分子量 | 743.11 |
EINECS号 | |
相关类别 | |
Mol文件 | 1021868-83-6.mol |
结构式 |
ARL 67156 性质
储存条件 | Desiccate at -20°C |
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溶解度 | <15.78mg/ml,在水中 |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | Soluble to 20 mM in water |
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg).
Animal Model: | C57BL/6 mice |
Dosage: | 2 mg/kg |
Administration: | Pre-treated (i.p.) 1 h before administration of FBP (100 mg/kg) |
Result: | Completely prevented the increase of serum adenosine concentration induced by FBP. |