千里光宁
中文名称 | 千里光宁 |
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中文同义词 | 千里光宁;千里光寧鹼;千里光宁碱;千里光碱/ 千里光宁;千里光宁 标准品;甲醇中千里光宁碱标准溶液 |
英文名称 | SENECIONINE |
英文同义词 | (15cis)-12-Hydroxysenecionan-11,16-dione;12-Hydroxysenecionan-11,16-dione;16-dione,12-hydroxy-senecionan-1;Aureine;Sencionine;Senecionan-11,16-dione, 12-hydroxy-;SENECIONINE;Senecionine/Aureine |
CAS号 | 130-01-8 |
分子式 | C18H25NO5 |
分子量 | 335.39 |
EINECS号 | |
相关类别 | 植物提取物;植物活性成分;植物提取;对照品;对照品;Alkaloids;标准品-对照品;生物碱;标准品,对照品;标准品 |
Mol文件 | 130-01-8.mol |
结构式 |
千里光宁 性质
熔点 | 236 °C(lit.) |
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比旋光度 | D25 -55.1° (c = 0.034 in chloroform) |
沸点 | 472.03°C (rough estimate) |
密度 | 1.266 g/cm3 |
折射率 | 1.5100 (estimate) |
储存条件 | −20°C |
溶解度 | DMF:5mg/mL; DMSO:2mg/mL;乙醇:1mg/mL; PBS(pH 7.2):0.1 mg/mL |
酸度系数(pKa) | 12.81±0.40(Predicted) |
旋光性 (optical activity) | [α]25/D 55.1°, c = 0.034% in chloroform |
BRN | 8162955 |
InChIKey | HKODIGSRFALUTA-JTLQZVBZSA-N |
LogP | 0.880 (est) |
EPA化学物质信息 | Senecionine (130-01-8) |
Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.
Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.
安全信息
危险品标志 | T |
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危险类别码 | 25 |
安全说明 | 45 |
危险品运输编号 | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS号 | VT5710000 |
F | 10-23 |
危险等级 | 6.1(a) |
包装类别 | II |
毒害物质数据 | 130-01-8(Hazardous Substances Data) |
毒性 | LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris) |
提供商 | 语言 |
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英文
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