阿米卡星硫酸盐(5:9)
| 中文名称 | 阿米卡星硫酸盐(5:9) |
|---|---|
| 中文同义词 | 阿米卡霉素硫酸;磺胺甲恶唑149022-22-0;硫酸阿米卡星149022-22-0;硫酸阿米卡星;硫酸阿米卡星(5:9);O-3-氨基-3-脱氧-Α-D-吡喃葡萄糖基-(1→6)-O-[6-氨基-6-脱氧-Α-D-吡喃葡萄糖基-(1→4)]-N1-[(2S)-4-氨基-2-羟基-1-氧丁基]-2-脱氧-D-链胺硫酸盐(5:9);阿米卡星硫酸盐(5:9);(S)-4-氨基-N-((1R,2S,3S,4R,5S)-5-氨基-2-(((2S,3R,4S,5S,6R)-4-氨基-3,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-4-(((2R,3R,4S,5S,6R)-6-(氨基甲基)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)-3-羟基环己基)-2-羟基丁酰胺硫酸盐(5:9) |
| 英文名称 | Amikacin sulfate salt |
| 英文同义词 | AMIKACIN SULFATE 1:1.8;Amikacin sulfate salt;(2S)-4-AMino-N-{(1R,2S,3S,4R,5S)-5-aMino-2-[(3-aMino-3-deoxy-a-D-glucopyranosyl)oxy]-4-[(6-aMino-6-deoxy-a-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanaMide sulfate (1:2);AMIKASIN SULFATE;AMIKACIN SULFATE SALT, AMINOGLYCOSID;Amikacin sulfate(5:9);mikacin disulfate salt;liusuanamukaxonm |
| CAS号 | 149022-22-0 |
| 分子式 | C22H45N5O17S |
| 分子量 | 683.68 |
| EINECS号 | 254-648-6 |
| 相关类别 | 医药原料;抗感染药物;医药与生物化工;原料药;化合物：原料药;医药兽药;医药原料药-科研原料;中间体;原料中间体-原料药;精细化工;医用原料;医用原料;兽药原料药;APIs;饲料添加剂;兽药原料;抗生素类;化学原料 |
| Mol文件 | 149022-22-0.mol |
| 结构式 |  |
阿米卡星硫酸盐(5:9) 性质
| 储存条件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | H2O中可溶50mg/mL |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 生物来源 | synthetic |
| InChIKey | HIBICIOPDUTNRR-BOEHXBESSA-N |
Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by
Nocardia asteroides
,
Mycobacterium avium-intracellulare
, and certain species of "rapid-growing" mycobacteria (that is,
M. chelonae
and
M. fortuitumi
).
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD
50
value of 453 μM.
Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo.
| Animal Model: | Male Fischer 344 rats (40-50-day-old) |
| Dosage: | 320 mg/kg |
| Administration: | Subcutaneous injection; daily; for 10 days |
| Result: | Induced hearing loss in rats. |
安全信息
| WGK Germany | 2 |
|---|---|
| RTECS号 | WK1961200 |