1H-Benz[de]isoquinoline-2(3H)-butanamide

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Products Intro: Product Name:NULLSCRIPT
CAS:300816-11-9
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:Nullscript
CAS:300816-11-9
Purity:NLT 98% Remarks:MC547212
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Products Intro: Product Name:4-thiophen-2-ylbenzoic acid
CAS:300816-11-9
Purity:0.97 Package:mgs,gs,kgs Remarks:A820181
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Products Intro: Product Name:Nullscript
CAS:300816-11-9
Purity:98% Package:1mg;5mg;10mg
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Products Intro: Product Name:Nullscript
CAS:300816-11-9
Purity:≥98% Remarks:Nullscript is an analog of scriptaid, a histone deacetylase (HDAC) inhibitor. Nullscript has no inhibitory effect against HDAC and acts as a negative control of scriptaid.
1H-Benz[de]isoquinoline-2(3H)-butanamide Basic information
Product Name:1H-Benz[de]isoquinoline-2(3H)-butanamide
Synonyms:1H-Benz[de]isoquinoline-2(3H)-butanamide, N-hydroxy-1,3-dioxo- (9CI);1H-Benz[de]isoquinoline-2(3H)-butanamide, N-hydroxy-1,3-dioxo-
CAS:300816-11-9
MF:C16H14N2O4
MW:298.29
EINECS:
Product Categories:
Mol File:300816-11-9.mol
1H-Benz[de]isoquinoline-2(3H)-butanamide Structure
1H-Benz[de]isoquinoline-2(3H)-butanamide Chemical Properties
Melting point 171-172℃
storage temp. −20°C
solubility ≤2mg/ml in DMSO;2mg/ml in dimethyl formamide
form Yellow to off-white solid.
Sensitive Light Sensitive
Safety Information
Safety Statements 22-24/25
MSDS Information
1H-Benz[de]isoquinoline-2(3H)-butanamide Usage And Synthesis
DefinitionChEBI: 4-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxybutanamide is a member of isoquinolines.
Biological Activitynullscript is an hdac inhibitor.histone deacetylase inhibitors (hdis) have been used in psychiatry and neurology as mood stabilizers and anti-epileptics, such as valproic acid. recently, hdis are being studied as a mitigator or treatment for neurodegenerative diseases. moreover, there has been an effort to develop hdis for cancer therapy.
in vitronullscript, a close analog of scriptaid, was found to be inactive in transcriptional facilitation at corresponding concentrations, which confirmed a minimal requirement for the length of the linker chain expected for this class of hdac inhibitors. in addition, nullscript was not able to induce the p6sbe-luc reporter construct, which was identified from the library using chemfinder by its structural similarity to scriptaid [1].
in vivoa standard in vivo model of cardiac i/rwe was utilized to examine the in vivo consequences of hdac inhibition in the intact heart. results showed that the treatment with scriptaid led to a nearly identical effect when compared to nullscript, with a 46.8% reduction in infarct size. such results strongly suggested that in murine models, hdacis could reverse the induction of ischemia-induced hdac activity and reduced myocardial infarct size by more than 50% [2].
references[1] g. h. su, t. a. sohn, b. ryu, et al. a novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. cancer research 60, 3137-3142 (2000).
[2] anne granger et al. histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. faseb j. 2008 oct; 22(10): 3549–3560.
1H-Benz[de]isoquinoline-2(3H)-butanamide Preparation Products And Raw materials
Tag:1H-Benz[de]isoquinoline-2(3H)-butanamide(300816-11-9) Related Product Information
TRICHOSTATIN A BML-210 Sodium Butyrate Suberohydroxamic acid SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE APICIDIN CAY10603 OXAMFLATIN Tubacin Entinostat HC TOXIN M344 Parthenolide 1H-Benz[de]isoquinoline-2(3H)-butanamide N-N-BUTYL-1,8-NAPHTHALIMIDE