| Company Name: |
ShangHai ChuanQian Chemcial Technique Centre
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15869524721 |
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| Products Intro: |
Product Name:TASIN-1 Hydrochloride
CAS:1678515-13-3
Purity:98% HPLC Package:5MG;10MG;50MG;100MG;1G;5G;10G
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TASIN-1 hydrochloride manufacturers
- TASIN-1 Hydrochloride
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- $71.00 / 1mg
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2025-11-10
- CAS:1678515-13-3
- Min. Order:
- Purity: 99.94%
- Supply Ability: 10g
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| | TASIN-1 hydrochloride Basic information |
| Product Name: | TASIN-1 hydrochloride | | Synonyms: | TASIN-1 hydrochloride;TASIN-1 hydrochloride >=98% (HPLC);TASIN 1 HCl;TASIN1 HCl;TASIN-1 HCl;TASIN 1 Hydrochloride,TASIN1 Hydrochloride;TASIN-1 Hydrochloride, 10 mM in DMSO | | CAS: | 1678515-13-3 | | MF: | C18H29ClN2O3S | | MW: | 388.95 | | EINECS: | | | Product Categories: | | | Mol File: | 1678515-13-3.mol |  |
| | TASIN-1 hydrochloride Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO (20 mg/ml) | | form | solid | | color | White to off-white | | Water Solubility | H2O: 2mg/mL, clear | | Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| | TASIN-1 hydrochloride Usage And Synthesis |
| Description | TASIN-1 (1678515-13-3) selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line.? It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer.? TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2 | | Uses | TASIN-1 hydrochloride is a selective inhibitor of truncated APC gene (adenomatous polyposis coli gene) and exerts cytotoxic effects through inhibition of cholesterol biosynthesis. TASIN-1 hydrochloride represents a potential strategy for prevention and intervention in CRC with mutant APC[1]. | | References | [1] LU ZHANG. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer[J]. Science Translational Medicine, 2016, 8 361. DOI:10.1126/scitranslmed.aaf8127
[2] LU ZHANG. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells.[J]. Molecular Cancer Therapeutics, 2018, 17 5: 943-951. DOI:10.1158/1535-7163.mct-17-0887 |
| | TASIN-1 hydrochloride Preparation Products And Raw materials |
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