A 77-01
| 中文名称 | A 77-01 |
|---|---|
| 中文同义词 | 4-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]喹啉;TGF-Β I型受体家族ALK5抑制剂(A 77-01);化合物A77-01;4-(3-(6-甲基吡啶-2-基)-1H-吡唑-4-基)喹啉 |
| 英文名称 | 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE |
| 英文同义词 | 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE;A 77-01;A-77-01;A77-01;4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01;4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline;CS-1775;4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline |
| CAS号 | 607737-87-1 |
| 分子式 | C18H14N4 |
| 分子量 | 286.33 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;小分子抑制剂;抑制剂;细胞生物学试剂;Inhibitors |
| Mol文件 | 607737-87-1.mol |
| 结构式 |  |
A 77-01 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 不溶于水； DMSO 中≥14.3 mg/mL；温和加热和超声波下，EtOH 中≥8.84 mg/mL |
| 形态 | 固体 |
A 77-01 是一种有效的 TGF-β I 型受体家族 ALK5 抑制剂，IC50 值为 25 nM。
IC50: 25 nM (ALK5)
A-77-01 (0.01-10 µM; 25 hours; Mv1Lu cells) treatment effectively inhibits TGF-β-induced transcriptional activation in concentration-dependent fashion.
A-77-01 (1 µM; 24-72 hours; Mv1Lu cells) treatment efficiently prevents the growth-inhibitory effects of TGF-β.
A-77-01 (1 µM; 30 minutes; HaCaT cells) treatment inhibits TGF-β-induced phosphorylation of Smad2.
RT-PCR
| Cell Line: | Mv1Lu cells |
| Concentration: | 0.01 µM, 0.03 µM, 0.1 µM, 0.3 µM, 1 µM, 3 µM, 10 µM |
| Incubation Time: | 25 hours |
| Result: | Inhibited the luciferase activity induced by TGF-β in concentration-dependent fashion. |
Cell Viability Assay
| Cell Line: | Mv1Lu cells |
| Concentration: | 1 µM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Efficiently prevented the growth-inhibitory effects of TGF-β. |
Western Blot Analysis
| Cell Line: | HaCaT cells |
| Concentration: | 1 µM |
| Incubation Time: | 30 minutes |
| Result: | Inhibited TGF-β-induced phosphorylation of Smad2. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-78349 | A 77-01 | 1 mg | 548元 | |
| 2024/01/25 | HY-78349 | A 77-01 A 77-01 | 607737-87-1 | 5mg | 1200元 |