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Chlorothiazide

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Company Name: PI & PI BIOTECH INC.
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Products Intro: Product Name:Hydrochlorothiazide impurity A (EP)
CAS:58-94-6
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (chlorothiazide)
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
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Products Intro: Product Name:Chlorothiazide
CAS:58-94-6
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:58-94-6
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
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Products Intro: Product Name:Chlorothiazide;Diuril;Chlorothiazid;Chlotride;Chlotride fandachem
CAS:58-94-6
Purity:As coa Package:As request Remarks:58-94-6
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
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Products Intro: Product Name:Chlorothiazide
CAS:58-94-6
Purity:98% Package:5g/25g/100g

Lastest Price from Chlorothiazide manufacturers

  • Chlorothiazide
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:58-94-6
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Chlorothiazide
  • US $7.00 / kg
  • 2019-07-06
  • CAS: 58-94-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Chlorothiazide Basic information
Product Name:Chlorothiazide
Synonyms:2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide;2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-,1,1-dioxide;Aldoclor;Alurene;Chloriazid;Chlorosal;Chlorothiazid;Chlorthiazide
CAS:58-94-6
MF:C7H6ClN3O4S2
MW:295.72
EINECS:200-404-9
Product Categories:DIURIL;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API
Mol File:58-94-6.mol
Chlorothiazide Structure
Chlorothiazide Chemical Properties
Melting point 342-343°C
Boiling point 608.8±65.0 °C(Predicted)
density 1.7303 (rough estimate)
refractive index 1.6100 (estimate)
storage temp. 2-8°C
form neat
pka6.85, 9.45(at 25℃)
Water Solubility <0.1 g/100 mL at 19.5 ºC
Merck 14,2168
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference58-94-6(CAS DataBase Reference)
NIST Chemistry ReferenceChlorothiazide(58-94-6)
EPA Substance Registry SystemChlorothiazide (58-94-6)
Safety Information
Hazard Codes Xn
Risk Statements 42/43-20/21/22
Safety Statements 36
WGK Germany 2
RTECS DK9450000
HS Code 2935904000
Hazardous Substances Data58-94-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Chlorothiazide English
SigmaAldrich English
Chlorothiazide Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorDiuril,Merck Sharp and,US,1957
UsesDiuretic; antihypertensive
UsesThis drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.
DefinitionChEBI: 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.
Manufacturing Process(A) m-Chloroaniline (64 g, 0.5 mol) was added dropwise with stirring to 375 ml of chlorosulfonic acid in a 3-liter round bottom, 3-necked flask cooled in an ice bath. Sodium chloride (350 g) was added portionwise over a period of 1 to2 hours and the mixture then heated gradually in an oil bath to 150°C. After 3 hours at 150° to 160°C, the flask was cooled thoroughly in an ice bath and the contents treated with a liter of cold water. The product was extracted with ether and the extract washed with water and dried over sodium sulfate.
After removal of ether on the steam bath, the residual 5-chloroaniline-2,4- disulfonyl chloride, which may be crystallized from benzene-hexane MP 130° to 132°C, was cooled in an ice bath and treated with 150 ml of 28% ammonium hydroxide in a 2-liter Erlenmeyer flask. The mixture was heated on the steam bath for 1 hour, cooled and the product collected on the filter, washed with water and dried. Upon crystallization from dilute alcohol 5- chloro-2,4-disulfamylaniline was obtained as colorless needles, MP 251° to 252°C.
(B) A solution of 88 g of 5-chloro-2,4-disulfamylaniline in 1.1 liters of 88% formic acid was heated under reflux for 2 hours. After removal of 200 ml of solvent by distillation, one liter of water was added and the product collected, washed with water and dried. Crystallization from dilute alcohol afforded 6- chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide as colorless needles, MP 342.5° to 343°C, as described in US Patent 2,809,194.
Brand nameDiuril (Ovation).
Therapeutic FunctionDiuretic; Antihypertensive
General DescriptionCrystals; white powder.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileAlkaline aqueous solutions will decompose on standing or heating .
Fire HazardFlash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.
Mechanism of actionThe diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.
Safety ProfileModerately_toxic by intraperitoneal and intravenous routes. Mddly toxic by ingestion. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx NOx and Cl-.
Chemical SynthesisChlorothiazide, 1,1-dioxide 6-chloro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.3) is synthesized in the exact same manner, is all thiazide diuretics. 3- Chloroaniline (or 3-trifluoromethylaniline) undergoes sulfoylchlorination by chlorosulfonic acid, forming 4,6-sulfonochloride-3-chloroaniline (21.3.1), the reaction of which with ammonia gives 4,6-sulfonylamido-3-chloroaniline (21.3.2). Heating this with formamide leads to formation of chlorothiazide (21.3.3).

Veterinary Drugs and TreatmentsIn veterinary medicine, furosemide has largely supplanted the use of thiazides as a general diuretic (edema treatment). Thiazides are still used for the treatment of systemic hypertension, nephrogenic diabetes insipidus, and to help prevent the recurrence of calcium oxalate uroliths in dogs.
Chlorothiazide is approved for use in dairy cattle for the treatment of post parturient udder edema, but the veterinary labeled product has been discontinued in the USA.
Chlorothiazide Preparation Products And Raw materials
Tag:Chlorothiazide(58-94-6) Related Product Information
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