番茄碱
中文名称 | 番茄碱 |
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中文同义词 | 番茄碱盐酸盐;水解番茄碱;盐酸西红柿碱;水解番茄硷盐酸盐;TOMATIDINE HYDROCHLORIDE, >85%;盐酸番茄碱标准品;盐酸番茄碱对照品;盐酸托马替丁 |
英文名称 | Tomatidine hydrochloride |
英文同义词 | 3BETA-HYDROXY-5ALPHA-TOMATIDANE HYDROCHLORIDE;5ALPHA-TOMATIDAN-3BETA-OL HYDROCHLORIDE;TOMATIDINE HCL;TOMATIDINE HYDROCHLORIDE;SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL;(3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride;TOMATIDINE HCL(RG);Tomatidine, Hydrochloride, >85% |
CAS号 | 6192-62-7 |
分子式 | C27H46ClNO2 |
分子量 | 452.11 |
EINECS号 | |
相关类别 | 医药中间体;标准品;标准品 -中药标准品;Lipid signaling;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
Mol文件 | 6192-62-7.mol |
结构式 |
番茄碱 性质
熔点 | 281-284°C (dec.) |
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储存条件 | 2-8°C |
溶解度 | 少许溶于甲醇 |
形态 | 类白色固体 |
颜色 | 白色至类白色 |
BRN | 3920740 |
p65
|
JNK
|
Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
提供商 | 语言 |
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英文
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