trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride

trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Basic information

Product Name:	trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride
Synonyms:	N-Methyl-N-[2α-(1-pyrrolidinyl)cyclohexan-1β-yl]-3,4-dichlorophenylacetamide;(+/-)-trans-U-50488;U50,488;2-(3,4-dichlorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylcyclohexyl)acetami de;trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide mesylate;rel-3,4-Dichloro-N-methyl-N-[(1α)-2β-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide;3,4-Dichloro-N-methyl-N-[(1β,2α)-2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide;3,4-Dichloro-N-methyl-N-[2α-(pyrrolidin-1-yl)cyclohexan-1β-yl]benzeneacetamide
CAS:	67198-13-4
MF:	C19H26Cl2N2O
MW:	369.33
EINECS:
Product Categories:	Opioid receptor and opioid-like receptor
Mol File:	67198-13-4.mol

trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Chemical Properties

Safety Information

MSDS Information

trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Usage And Synthesis

Uses	U 50488 is a selective κ-opioid agonist with analgesic, diuretic, and antitussive properties. κ-opioid agonists are useful compounds to elucidate the functions of κ-receptors in the central nervous system.
Definition	ChEBI: A monocarboxylic acid amide obtained by formal condensation between the carboxy group of 3,4-dichlorophenylacetic acid and the secondary amino group of (1R,2R)-N-methyl-2-(pyrrolidin-1-yl)cyclohexanamine
Biological Activity	Selective κ -opioid agonist. At higher concentrations blocks Na + channels. See separate isomers (trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride and 0471 ).

trans-(-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamidehydrochloride Preparation Products And Raw materials

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