龙胆苦苷
中文名称 | 龙胆苦苷 |
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中文同义词 | 龙胆苦甙;龙胆苦苷;GENTIOPICROSIDE 龙胆苦苷;龙胆苦苷 20MG;龙胆提取物.龙胆苦甙;龙胆苦苷(龙胆苦甙);龙胆苦苷(标准品);龙胆苦苷(分析标准品) |
英文名称 | Gentiopicroside |
英文同义词 | 1H,3H-Pyrano[3,4-c]pyran-1-one,5-ethenyl-6-(β-D-;glucopyranosyloxy)-5,6-dihydro-,(5R-trans)-;(5R,6S)-5-ethenyl-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6-dihydro-3H-pyrano[5,4-c]pyran-1-one;1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-, (5R,6S)- ;1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-, (5R-trans)-;(5R)-5β-Ethenyl-6α-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one;(5R)-5β-Vinyl-6α-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one;GENTIOPICROSIDE |
CAS号 | 20831-76-9 |
分子式 | C16H20O9 |
分子量 | 356.33 |
EINECS号 | 244-070-2 |
相关类别 | 中草药成分;植物提取物;中药对照品;标准品;对照品,标准品;分析标准品;对照品;植提标准品;中药标准品;医药中间体;小分子抑制剂;小分子抑制剂,天然产物;单体;标准品-对照品;标准品-中药标准品;Iridoids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;植物成分单体;其他原料;标准品 -中药标准品;环烯醚萜;分析试剂-对照品;高纯分离试剂;高纯分离试剂-标准品;单体化合物;标准提取物;通用生化试剂-天然产物;生物化工 |
Mol文件 | 20831-76-9.mol |
结构式 |
龙胆苦苷 性质
熔点 | 191°C |
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比旋光度 | -200 º (c=2, H2O) |
沸点 | 667.8±55.0 °C(Predicted) |
密度 | 1.52±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C(protect from light) |
溶解度 | 可溶于DMSO(轻微)、乙醇(轻微、超声处理) |
形态 | 固体 |
酸度系数(pKa) | 12.79±0.70(Predicted) |
颜色 | 浅米色 |
稳定性 | 吸湿性 |
LogP | -3.170 (est) |
CAS 数据库 | 20831-76-9(CAS DataBase Reference) |
龙胆苦苷是一种天然的环烯醚萜苷,能够抑制 P450 的活性,对 CYP2A6 的 IC50 和 Ki 值分别为 61 µM 和 22.8 µM;Gentiopicroside 具有抗炎和抗氧化活性。
Target | Value |
CYP2A6
(in human liver microsomes) | |
CYP2E1
(in human liver microsomes) |
Gentiopicroside inhibits P450 activity, with an IC 50 and a K i of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC 50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption.
Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice.
药理药效:具有利胆、抗炎、健胃、降压等作用。
安全信息
海关编码 | 29389090 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | 46683 | 龙胆苦苷 Gentiopicroside | 20831-76-9 | 250mg | 3526元 |
2024/08/19 | 46683 | 龙胆苦苷 Gentiopicroside | 20831-76-9 | 1g | 9417元 |