托泊地芬
| 中文名称 | 托泊地芬 |
|---|---|
| 中文同义词 | 托泊地芬;化合物 T13211;化合物 TROPODIFENE |
| 英文名称 | Tropodifene |
| 英文同义词 | Tropodifene;Tropaphen;Benzenepropanoic acid, 4-(acetyloxy)-α-phenyl-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester;(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-(4-acetyloxyphenyl)-2-phenylpropanoate |
| CAS号 | 15790-02-0 |
| 分子式 | C25H29NO4 |
| 分子量 | 407.507 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 15790-02-0.mol |
| 结构式 |  |
托泊地芬 性质
| 沸点 | 508.5±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.20±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.99±0.40(Predicted) |
α-Adrenergic
Tropaphen has a beneficial effect on hypertension. The therapeutic effect of this preparation is more constant in diseases accompanied by spasm of the peripheral vessels. Tropaphen has a very marked adrenolytic and vasodilator action. It greatly lowers the tone of the peripheral vessels. The preparation is effective starting with a dose of 0.1 mg/kg. After injection of the drug in a dose of 0.25 mg/kg, a considerable and gradually progressive decrease in the perfusion pressure takes place. The pressure falls by 30-35% and remained at a low level for 90-100 min. With a dose of tropaphen of 0.5 mg/kg, the perfusion pressure falls by 40-45% and remains low for 120 min or more. Strong vasodilatation is also observed after injection of tropaphen into intact rabbits.