4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉
| 中文名称 | 4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉 |
|---|---|
| 中文同义词 | 4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉;4-(4\'-羟基苯基)氨基-6,7-二甲氧基喹唑啉, >98%;JAK3抑制剂(JANEX-1);化合物WHI-P131;4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉;4-((6,7-二甲氧基喹唑啉-4-基)氨基)苯酚;3-氰基-5-[[3;5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈 |
| 英文名称 | JAK3 INHIBITOR I |
| 英文同义词 | 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE;JAK3 INHIBITOR I;WHI-P131;Janex 1;A JAK3 inhibitor WHI-P131;4-(6,7-dimethoxyquinazolin-4-ylamino)phenol;WHI-P131(Janex 1);JANEX-1;WHI-P131 |
| CAS号 | 202475-60-3 |
| 分子式 | C16H15N3O3 |
| 分子量 | 297.31 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;标准品;Inhibitors;Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 202475-60-3.mol |
| 结构式 |  |
4-(4'-羟基苯基)氨基-6,7-二甲氧基喹唑啉 性质
| 沸点 | 468.1±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.336±0.06 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 溶解度 | 在DMSO中的溶解度为18 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.06±0.26(Predicted) |
| 颜色 | 粘黄色 |
| 稳定性 | 自购买之日起 2 年内保持稳定。防潮。 DMSO 溶液可在 -20°C 下保存长达 2 个月。 |
| Target | Value |
|
JAK3
(Cell-free assay) | 78 μM |
JANEX-1 (WHI-P131) shows potent JAK3-inhibitory activity (IC 50 of 78 μM), does not inhibit JAK1 and JAK2, the ZAP/SYK family tyrosine kinase SYK, the TEC family tyrosine kinase BTK, the SRC family tyrosine kinase LYN, or the receptor family tyrosine kinase insulin receptor kinase, even at concentrations as high as 350 μM. JANEX-1 induces apoptosis in JAK3-expressing human leukemia cell lines NALM-6 and LC1;19 but not in melanoma (M24-MET) or squamous carcinoma (SQ20B) cells. WHI-P131 inhibits the clonogenic growth of JAK3-positive leukemia cell lines DAUDI, RAMOS, LC1;19, NALM-6, MOLT-3, and HL-60 (but not JAK3-negative BT-20 breast cancer, M24-MET melanoma, or SQ20B squamous carcinoma cell lines) in a concentration-dependent fashion. WHI-P131 inhibits clonogenic growth in a concentration-dependent fashion with EC 50 s of 24.4 μM for NALM-6 cells and 18.8 μM for DAUDI cells. At 100 μM, WHI-P131 inhibits the in vitro colony formation by these leukemia cell lines by >99%. In contrast, JANEX-1 does not inhibit the clonogenic growth of JAK3-negative M24-MET melanoma or SQ20B squamous carcinoma cell lines.
JANEX-1 is administered at doses ranging from 5 to 100 mg/kg. Evaluation of CPK activity revealed a dose-response curve with an effective dose 50 (ED 50 ) value of 7.44 mg/kg. Mice receiving JANEX-1 displayed significantly reduced CPK and LDH levels. In addition, the infarct size of JANEX-1-treated mice (30.16±2.79%) is significantly decreased when compared with I/R-operated mice (65.64±3.76%). JANEX-1 (WHI-P131) is absorbed rapidly, and the time to reach the maximum plasma JANEX-1 concentration (t max ) is 24.7±1.7 min. JANEX-1 is rapidly eliminated with an elimination half-life of 45.6±5.5 min. Although the predicted maximum plasma JANEX-1 concentration is 10.5 ± 0.8 μM, which is only half of the C max following i.v. administration of the same bolus dose, the i.p. bioavailability is 94.6% and the systemic exposure levels (i.e., AUC) are very similar to those observed after i.v. injection (17.1±2.2 μM•h versus 18.1±1.2 μM•h).
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15508 | JANEX-1 | 1 mg | 431元 | |
| 2024/04/30 | XW20247560301 | 4-(4\’-羟基苯基)氨基-6,7-二甲氧基喹唑啉 | 202475-60-3 | 50MG | 496元 |