Company Name: |
Sigma-Aldrich
|
Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:Trapoxin A CAS:133155-89-2 Purity:>=98% (HPLC) Package:1mg, 5mg Remarks:T2580
|
Company Name: |
BOC Sciences
|
Tel: |
16314854226 |
Email: |
info@bocsci.com |
Products Intro: |
Product Name:Trapoxin A CAS:133155-89-2 Purity:98% Package:1G;10G;100G Remarks:Trapoxin A is an irreversible cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner.
|
Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:Trapoxin A CAS:133155-89-2 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
Company Name: |
InvivoChem
|
Tel: |
13549236410 |
Email: |
sales@invivochem.cn |
Products Intro: |
Product Name:Trapoxin A CAS:133155-89-2 Purity:>=98% Package:98% Remarks:V41375
|
|
| trapoxin A Basic information |
Product Name: | trapoxin A | Synonyms: | trapoxin A;(4aR,7S,10S,13S)-10,13-Dibenzyl-7-[6-oxo-6-[(S)-oxiranyl]hexyl]-1,2,3,4,9,10-hexahydro-4aH-6,9,12,14a-tetraazabenzocyclododecene-5,8,11,14(6H,7H,12H,13H)-tetrone;Cyclo[L-Phe-L-Phe-D-Hpr-6-[2-[(S)-oxiranyl]-2-oxoethyl]-L-Nle-];RF-1023A;Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl);Cyclo[(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl];Cyclo[(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-(2R)-2-piperidinecarbonyl] | CAS: | 133155-89-2 | MF: | C34H42N4O6 | MW: | 602.72 | EINECS: | | Product Categories: | | Mol File: | 133155-89-2.mol | |
| trapoxin A Chemical Properties |
storage temp. | -20°C | solubility | DMSO: soluble0.9-1.10 mg/ml, clear, colorless to faintly yellow (may be further diluted 20 fold in H2O) | form | solid |
Hazard Codes | T | Risk Statements | 25 | Safety Statements | 45 | RIDADR | UN 2811 6.1 / PGIII | WGK Germany | 3 |
| trapoxin A Usage And Synthesis |
Description | Trapoxin A is a cyclotetrapeptide histone deacetylase (HDAC) inhibitor. It inhibits HDAC activity in a concentration-dependent and irreversible manner. Trapoxin A inhibits proliferation of NIH3T3 cells transformed by the oncogene v-sis (sis/NIH3T3; IC50 = ~200 ng/ml) and has detransformation activity, flattening sis/NIH3T3 cells when used at a concentration of 1 ng/ml. It also halts the cell cycle at the G2 phase in 3Y1 fibroblasts when used at a concentration of 10 nM and inhibits growth of TR303 cells resistant to trichostatin A at a concentration of 50 ng/ml. | Uses | Trapoxin A has been used:
- to study its effects on the inhibition of histone deacetylase 11 (HDAC11)
- to study its effects on the inhibition of HDAC3 in human cell lines
- to study its effects on the inhibition of HDAC6 in rat pyramidal neurons
| Definition | ChEBI: A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues. | Biochem/physiol Actions | Trapoxin A is a cyclotetrapeptide and a histone deacetylase (HDAC) inhibitor. It increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin A irreversibly inhibites HDAC activity in crude cell lysates, and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials. |
| trapoxin A Preparation Products And Raw materials |
|