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Product Name:1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one
CAS:28544-83-4
Purity:98% HPLC Package:5g, 10g, 25g, 100g, 500g
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| | 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Basic information |
| Product Name: | 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one | | Synonyms: | 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one;1,2,3,4-tetrahydro-5H-1,4-Benzodiazepin-5-one;3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one;1,2,3,4-Tetrahydro-1,4-benzodiazepin-5-one;5H-1,4-Benzodiazepin-5-one, 1,2,3,4-tetrahydro- | | CAS: | 28544-83-4 | | MF: | C9H10N2O | | MW: | 162.19 | | EINECS: | | | Product Categories: | | | Mol File: | 28544-83-4.mol |  |
| | 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Chemical Properties |
| Melting point | 143-145 °C | | Boiling point | 436.0±25.0 °C(Predicted) | | density | 1.137±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 14.00±0.20(Predicted) | | Appearance | White to yellow Solid |
| | 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Usage And Synthesis |
| Synthesis | Methyl 2-chlorobenzoate (5.00 g, 29.0 mmol), ethylenediamine (8.81 g, 146.7 mmol) and anhydrous potassium carbonate (8.10 g, 58.6 mmol) were dissolved in N,N-dimethylformamide (DMF, 100 mL) under nitrogen protection. The reaction mixture was stirred at room temperature for the reaction. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the DMF. water was added to the residue and extracted three times with ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to give a black residue. The residue was purified by silica gel column chromatography using gradient elution with ethyl acetate/petroleum ether (20-50%) to afford the white solid product 3,4-dihydro-1H-benzo[e][1,4]diazepan-5(2H)-one (2.5 g, 52.6% yield). | | References | [1] Patent: CN108498520, 2018, A. Location in patent: Paragraph 0025; 0027; 0028; 0029; 0030 |
| | 1,2,3,4-tetrahydrobenzo(e)(1,4)diazepin-5-one Preparation Products And Raw materials |
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