ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT
生物活性靶点体外研究体内研究 用途与合成方法 MSDS ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT价格(试剂级) 上下游产品信息
| 中文名称 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT |
|---|---|
| 中文同义词 | (R)-腺苷 环3',5'-(硫代磷酸氢酯)三乙胺盐;化合物 T12764;ADENOSINE 3,5-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT CALBIOCHEM;腺苷-3'',5''-环状硫代磷酸三乙基铵盐 |
| 英文名称 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT |
| 英文同义词 | adenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-camps),triethylammonium;CAMPS-RP, TRIETHYLAMMONIUM SALT;CAMPS TEA, RP-ISOMER;ADENOSINE-3',5'-CYCLIC-MONOPHOSPHOROTHIOATE TRIETHYLAMMONIUM SALT RP ISOMER;ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER TRIETHYLAMMONIUM SALT;ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-RP, TRIETHYLAMMONIUM SALT;ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT;RP-CAMPS TRIETHYL AMMONIUM SALT |
| CAS号 | 151837-09-1 |
| 分子式 | C16H27N6O5PS |
| 分子量 | 446.46 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 151837-09-1.mol |
| 结构式 |  |
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | H2O：可溶，10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble to 100 mM in water |
Rp-cAMPS triethylammonium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。
Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.
安全信息
| WGK Germany | 3 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100530 | ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT Rp-cAMPS triethylammonium salt | 151837-09-1 | 1mg | 6750元 |