4-P-PDOT
| 中文名称 | 4-P-PDOT |
|---|---|
| 中文同义词 | N-(4-苯基-1,2,3,4-四氢-2-萘基)丙酰胺;4-P-PDOT,MT 2褪黑激素受体拮抗剂;4-苯基-2-丙酰胺四氢萘;4-P-PDOT,MT2 SELECTIVE MELATONIN RECEPTOR拮抗剂;化合物4-P-PDOT,10 MM DMSO 溶液 |
| 英文名称 | 4-P-PDOT |
| 英文同义词 | 4-PHENYL-2-PROPIONAMIDOTETRALIN;4-P-PDOT;N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide;4-P-PDOT; 4PPDOT; 4P-PDOT; AH-024; 4-PHENYL-2- PROPIONAMIDOTETRALIN.;AH-024;Propanamide, N-(1,2,3,4-tetrahydro-4-phenyl-2-naphthalenyl)-;N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide;Melatonin,Melatonin Receptor,GSSG,Nrf2,GSH,4PPDOT,ERK,memory,damage,Inhibitor,oxidative,4 P PDOT,MT2,inhibit |
| CAS号 | 134865-74-0 |
| 分子式 | C19H21NO |
| 分子量 | 279.38 |
| EINECS号 | |
| 相关类别 | Melatonin receptor |
| Mol文件 | 134865-74-0.mol |
| 结构式 |  |
4-P-PDOT 性质
| 熔点 | 166 °C |
|---|---|
| 沸点 | 480.1±45.0 °C(Predicted) |
| 密度 | 1.11±0.1 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | 溶于 DMSO > 10 mM |
| 酸度系数(pKa) | 15.87±0.40(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChI | 1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21) |
| InChIKey | RCYLUNPFECYGDW-UHFFFAOYSA-N |
| SMILES | N(C1CC(c3c(cccc3)C1)c2ccccc2)C(=O)CC |
MT2 receptor
In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. In contrast, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC 50 value of 8.72 and intrinsic activity of 0.86.
Cell Viability Assay
| Cell Line: | HT-29 and HeLa cells. |
| Concentration: | 30 min. |
| Incubation Time: | 50 µM. |
| Result: | Produced a negligible effect on cell viability induced by melatonin. |
4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice.
| Animal Model: | Klotho mutant mice treatment with Melatonin |
| Dosage: | 0.5 mg/kg or 1.0 mg/kg |
| Administration: | Intravenous injection |
| Result: | Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| RTECS号 | TX1498350 |
| 海关编码 | 2924.29.7790 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 急性毒性 类别4 经口 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-100609 | 4-P-PDOT 4-P-PDOT | 134865-74-0 | 1mg | 394元 |
| 2025/12/22 | HY-100609 | 4-P-PDOT 4-P-PDOT | 134865-74-0 | 5mg | 900元 |