4-P-PDOT
中文名称 | 4-P-PDOT |
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中文同义词 | N-(4-苯基-1,2,3,4-四氢-2-萘基)丙酰胺;4-P-PDOT,MT 2褪黑激素受体拮抗剂 |
英文名称 | 4-P-PDOT |
英文同义词 | 4-PHENYL-2-PROPIONAMIDOTETRALIN;4-P-PDOT;N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide;4-P-PDOT; 4PPDOT; 4P-PDOT; AH-024; 4-PHENYL-2- PROPIONAMIDOTETRALIN.;AH-024;Propanamide, N-(1,2,3,4-tetrahydro-4-phenyl-2-naphthalenyl)-;N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide;Melatonin,Melatonin Receptor,GSSG,Nrf2,GSH,4PPDOT,ERK,memory,damage,Inhibitor,oxidative,4 P PDOT,MT2,inhibit |
CAS号 | 134865-74-0 |
分子式 | C19H21NO |
分子量 | 279.38 |
EINECS号 | |
相关类别 | Melatonin receptor |
Mol文件 | 134865-74-0.mol |
结构式 |
4-P-PDOT 性质
熔点 | 166 °C |
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沸点 | 480.1±45.0 °C(Predicted) |
密度 | 1.11±0.1 g/cm3(Predicted) |
储存条件 | room temp |
溶解度 | 溶于 DMSO > 10 mM |
酸度系数(pKa) | 15.87±0.40(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
MT2 receptor
In CHO-mt1 cells the amidotetraline 4-P-PDOT (10 mM) has no effect on forskolin-stimulated cyclic AMP levels, either alone, or in the presence of Melatonin. In contrast, in CHO-MT2 cells, 4-P-PDOT is an agonist, producing a concentration-dependent inhibition of forskolin stimulated cyclic AMP, with a pEC 50 value of 8.72 and intrinsic activity of 0.86.
Cell Viability Assay
Cell Line: | HT-29 and HeLa cells. |
Concentration: | 30 min. |
Incubation Time: | 50 µM. |
Result: | Produced a negligible effect on cell viability induced by melatonin. |
4-P-PDOT (0.5-1.0 mg/kg; intravenous injection; klotho mutant mice) treatment significantly reverses antioxidant effects mediated by Melatonin. And significantly reverses the changes in the levels of these GSH-related parameters. 4-P-PDOT treatment significantly reverses the memory function of Melatonin-treated klotho mutant mice. 4-P-PDOT also counteracts Melatonin-mediated attenuation in response to the decreases in phospho-ERK expression, Nrf2 nuclear translocation, Nrf2 DNA-binding activity, and GCL mRNA expression in the hippocampi of klotho mutant mice.
Animal Model: | Klotho mutant mice treatment with Melatonin |
Dosage: | 0.5 mg/kg or 1.0 mg/kg |
Administration: | Intravenous injection |
Result: | Significantly reversed antioxidant effects mediated by Melatonin. Significantly reversed the changes in the levels of these GSH-related parameters. Significantly reversed the memory function of Melatonin-treated klotho mutant mice. |
安全信息
RTECS号 | TX1498350 |
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海关编码 | 2924.29.7790 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | P2587 | 4-P-PDOT 4-P-PDOT | 134865-74-0 | 5mg | 290元 |
2024/04/30 | P2587 | 4-P-PDOT 4-P-PDOT | 134865-74-0 | 25mg | 735元 |