| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:LY 487379 hydrochloride;2,2,2-Trifluoro-N-[4-(2-Methoxyphenoxy)phenyl]-N-(3-pyridinylMethyl)ethanesulfonaMidehydrochloride
CAS:353231-17-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
|
| Tel: |
025-58196018 800028039 |
| Email: |
sales@fartop.net |
| Products Intro: |
Product Name:EthanesulfonaMide, 2,2,2-trifluoro-N-[4-(2-Methoxyphenoxy)phenyl]-N-(3-pyridinylMethyl)-
CAS:353231-17-1
Purity:97%
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- LY487379
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- $40.00 / 2mg
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2026-01-05
- CAS:353231-17-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | LY 487379 HYDROCHLORIDE Basic information |
| Product Name: | LY 487379 HYDROCHLORIDE | | Synonyms: | EthanesulfonaMide, 2,2,2-trifluoro-N-[4-(2-Methoxyphenoxy)phenyl]-N-(3-pyridinylMethyl)-;2,2,2-Trifluoro-N-(4-(2-methoxyphenoxy)phenyl)-N-(pyridin-3-ylmethyl)ethanesulfonamide;LY 487379 HYDROCHLORIDE;2,2,2-Trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamidehydrochloride;2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(3-pyridinylmethyl)ethanesulfonamide;LY 487379 hydrochlor | | CAS: | 353231-17-1 | | MF: | C21H19F3N2O4S | | MW: | 452.45 | | EINECS: | | | Product Categories: | | | Mol File: | 353231-17-1.mol |  |
| | LY 487379 HYDROCHLORIDE Chemical Properties |
| storage temp. | Sealed in dry,2-8°C | | solubility | DMSO : 100 mg/mL (221.02 mM; Need ultrasonic) | | form | Solid | | color | Off-white to light yellow |
| | LY 487379 HYDROCHLORIDE Usage And Synthesis |
| Uses | LY 487379 is a positive allosteric modulator selective for mGluR-2. | | Uses | LY 487379 Hydrochloride is a group II mGlu receptors activator with anti-hyperthermic effects. Allosteric potentiators of metabotropic glutamate receptor 2 (mGlu2). | | Biological Activity | Positive allosteric modulator selective for mGlu 2 receptors. Potentiates glutamate-stimulated [ 35 S]GTP γ S binding (EC 50 values are 1.7 and > 10 μ M for mGlu 2 and mGlu 3 receptors respectively). Devoid of any activity at mGlu 5 and mGlu 7 receptors. | | in vivo | LY487379 (intraperitoneal injection; 30 mg/kg; injected 30 min before the test) requires significantly fewer trials to criterion during the ED phase of the ASST in attentional set-shifting task in male Sprague-Dawley rats. But there has no significant drug effect during any other discrimination stage[1].LY487379 hydrochloride (intraperitoneal injection; 10-30 mg/kg) induces an increase in microdialysate norepinephrine levels; the dose-effect resembled a bell-shape relationship increased. And it dose-dependently increases extracellular serotonin levels in the medial prefrontal cortex in male Sprague-Dawley rats[1]. |
| | LY 487379 HYDROCHLORIDE Preparation Products And Raw materials |
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