1333210-07-3
| 中文名称 | 1333210-07-3 |
|---|---|
| 中文同义词 | SAR7334游离态;化合物SAR7334;4-(((1R,2R)-2-((R)-3-氨基哌啶-1-基)-2,3-二氢-1H-茚-1-基)氧基)-3-氯苯甲腈;4-[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氢-1H-茚-1-基]氧基]-3-氯苄腈 |
| 英文名称 | Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro- |
| 英文同义词 | Benzonitrile, 4-[[(1R,2R)-2-[(3R)-3-aMino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloro-;TRCP6 inhibitor;TRCP6-IN-1;4-(((1R,2R)-2-((R)-3-Aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile;SAR7334;SAR7334,SAR 7334,TRP Channel,SAR-7334,Inhibitor,inhibit,Transient receptor potential channels |
| CAS号 | 1333210-07-3 |
| 分子式 | C21H22ClN3O |
| 分子量 | 367.87 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1333210-07-3.mol |
| 结构式 |  |
1333210-07-3 性质
| 沸点 | 534.6±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.30±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 不溶于水；乙醇中≥106.4 mg/mL； DMSO 中≥125.4 mg/mL |
| 酸度系数(pKa) | 10.95±0.20(Predicted) |
| Target | Value |
|
TPRC6
(Cell-free assay) | 7.9nM |
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca 2+ influx into cells with IC 50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca 2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC 50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.
SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15699 | SAR7334 | 1 mg | 909元 | |
| 2024/04/30 | HY-15699 | 1333210-07-3 SAR7334 | 1333210-07-3 | 5mg | 2000元 |