(+)-AEROPLYSININ-1
| 中文名称 | (+)-AEROPLYSININ-1 |
|---|---|
| 中文同义词 | (+)-AEROPLYSININ-1;化合物 T23645 |
| 英文名称 | (+)-AEROPLYSININ-1 |
| 英文同义词 | (+)-aeroplysinini;(1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit;4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr;aeroplysinini;AEROPLYSININ;(+)-AEROPLYSININ-1;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA;AEROPLYSININ, APLYSINA AEROPHOBA |
| CAS号 | 28656-91-9 |
| 分子式 | C9H9Br2NO3 |
| 分子量 | 338.98 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 28656-91-9.mol |
| 结构式 |  |
(+)-AEROPLYSININ-1 性质
| 沸点 | 479.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 2.01±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 可溶于甲醇： |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.54±0.70(Predicted) |
|
Bacterial
|
HIV-1 14.6 μM (IC 50 ) |
Apoptosis
|
Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC
50
s ranging from 2.3 to 17 μM.
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity.
Aeroplysinin 1 inhibits
P. phosphoreum
,
C. wailesii
,
P. minimum
and HIV with IC
50
s of 3.5, 5.6, 7.0 and 14.6 μM.
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC
50
s ranging from 2.6 to 4.7 μM.
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro.
安全信息
| 海关编码 | 2941900000 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19827 | (+)-AEROPLYSININ-1 Aeroplysinin 1 | 28656-91-9 | 100 μg | 5800元 |