CS-2069
| 中文名称 | CS-2069 |
|---|---|
| 中文同义词 | ALDH1A1抑制剂(NCT-501);8-((4-(环丙基羰基)哌嗪-1-基)甲基)-7-异戊基-1,3-二甲基-1H-嘌呤-2,6(3H,7H)-二酮 |
| 英文名称 | NCT-501 |
| 英文同义词 | NCT-501;CS-2069;1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-;NCT-501 >=98% (HPLC);Inhibitor,Aldehyde Dehydrogenase (ALDH),inhibit,NCT-501,NCT 501;8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione |
| CAS号 | 1802088-50-1 |
| 分子式 | C21H32N6O3 |
| 分子量 | 416.52 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 1802088-50-1.mol |
| 结构式 |  |
CS-2069 性质
| 沸点 | 627.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | ≥20.85 mg/mL，溶于 DMSO，温和加热；不溶于水；乙醇中≥11 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.26±0.10(Predicted) |
NCT-501 是一种茶碱类的有效醛脱氢酶 1A1 (ALDH1A1) 选择性抑制剂, 抑制 hALDH1A1 时 IC50 值为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时, IC50值 >57 UM)。
IC50: 40 nM (hALDH1A1)
NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant.
NCT-501 (100 µg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.
| Animal Model: | 5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells) |
| Dosage: | 100µg/animal |
| Administration: | Intra-tumorally (i.t); every alternate day for 20 days |
| Result: | Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-18768 | NCT-501 | 1 mg | 727元 | |
| 2024/01/25 | HY-18768 | CS-2069 NCT-501 | 1802088-50-1 | 5mg | 1600元 |