尿石素C
| 中文名称 | 尿石素C |
|---|---|
| 中文同义词 | 尿石素C;3,8,9-三羟基-6H-苯并[C]色烯-6-酮 |
| 英文名称 | Urolithin C |
| 英文同义词 | 3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one;Urolithin C;3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-;Uro-C;insulin,Ca channels,Apoptosis,Polyphenols,ROS,mitochondria,anti-diabetic,gut-microbial,Reactive Oxygen Species,Inhibitor,Endogenous Metabolite,glucose-dependent,metabolite,Calcium Channel,β-cells,Urolithin C,ERK1/2,Ca2+ channels,inhibit;Urolithin C ( synthetic) |
| CAS号 | 165393-06-6 |
| 分子式 | C13H8O5 |
| 分子量 | 244.2 |
| EINECS号 | |
| 相关类别 | 对照品;HR140137 |
| Mol文件 | 165393-06-6.mol |
| 结构式 |  |
尿石素C 性质
| 熔点 | >300°C |
|---|---|
| 沸点 | 605.4±55.0 °C(Predicted) |
| 密度 | 1.640±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 可溶于DMSO（轻微）、甲醇（轻微、加热） |
| 酸度系数(pKa) | 7.51±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 灰白色至浅棕色 |
| 稳定性 | 吸湿性 |
| LogP | 1.615 (est) |
Insulin secretion
L-type Ca
2+
channel
Reactive oxygen species (ROS)
Apoptosis
Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells.
Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis.
Urolithin C treatment induces apoptosis and S phase cell cycle arrest.
Western Blot Analysis
| Cell Line: | INS-1 cells |
| Concentration: | 20 μM, 100 μM |
| Incubation Time: | 1 hour |
| Result: | Enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation. |
The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V 1 /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-135897 | Urolithin C | 5 mg | 620元 | |
| 2024/01/25 | HY-135897 | 尿石素C Urolithin C | 165393-06-6 | 10mM * 1mLin DMSO | 680元 |