NSC-624206
| 中文名称 | NSC-624206 |
|---|---|
| 中文同义词 | 化合物 T12265 |
| 英文名称 | NSC-624206 |
| 英文同义词 | NSC-624206;N-[3-(4-chlorophenyl)-3,3-disulfanylpropyl]decan-1-aminium chloride;N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride;NSC624206,NSC-624206;1-Decanamine, N-[2-[[(4-chlorophenyl)methyl]dithio]ethyl]-, hydrochloride (1:1) |
| CAS号 | 13116-77-3 |
| 分子式 | C19H33Cl2NS2 |
| 分子量 | 410.50802 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 13116-77-3.mol |
| 结构式 |  |
NSC-624206 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 在 DMSO 中溶解度为 50 mM，在乙醇中溶解度为 20 mM |
| 形态 | 粉末 |
NSC624206 是一种泛素 E1 (UBA1) 抑制剂，其 IC50 值为 ~9 μM。NSC624206 特异性地阻断泛素-硫代酯的形成，但对泛素腺化无影响。
IC50: ~9 μM (ubiquitin E1)
NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line.
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC
50
of 13 μM.
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells.
Western Blot Analysis
| Cell Line: | Kip16 cells |
| Concentration: | 10 nM-10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced accumulation of p27. |