N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
中文名称 | N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺 |
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中文同义词 | N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺;化合物PHCCC;PHCCC游离态;7-(肟基)-N-苯基-7,7A-二氢环丙烷[B]苯并哌喃-1A(1H)-酰胺;PHCCC,MGLU 4的变构增强剂 |
英文名称 | PHCCC |
英文同义词 | 7,7a-Dihydro-7-(hydroxyimino)-N-phenylbenzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide;Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-;PHCCC >=97% (HPLC);Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide,7,7a-dihydro-7-(hydroxyimino)-N-phenyl-,(7Z)-;(7Z)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide;(-) PHCCC;7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide;allosteric,disease,Metabotropic glutamate receptors,Inhibitor,PHCCC,neurons,neuroprotective,mGluR,Parkinson's,inhibit |
CAS号 | 179068-02-1 |
分子式 | C17H14N2O3 |
分子量 | 294.3 |
EINECS号 | |
相关类别 | |
Mol文件 | 179068-02-1.mol |
结构式 |
N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺 性质
储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 粉末 |
PHCCC 是一种 I 型 mGluR (Group I mGluR) 拮抗剂,IC50 为 3 μM,PHCCC 也是 mGlu4 受体选择性正向调节剂。具有抗帕金森病作用。
Group I mGluR receptors 3 μM (IC 50 ) |
PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.
PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.