ALKYNE-PEG8-BR
| 中文名称 | ALKYNE-PEG8-BR |
|---|---|
| 中文同义词 | 丙炔-八聚乙二醇-溴;炔-八聚乙二醇-溴;丙炔基-PEG8-溴;炔丙基-PEG8-溴;炔丙基-八聚乙二醇-溴 |
| 英文名称 | Propargyl-PEG8-bromide |
| 英文同义词 | Propargyl-PEG8-bromide;3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yne, 1-bromo-;Propargyl-PEG8-Br/3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yne, 1-bromo- |
| CAS号 | 2055046-25-6 |
| 分子式 | C19H35BrO8 |
| 分子量 | 471.38 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2055046-25-6.mol |
| 结构式 |  |
ALKYNE-PEG8-BR 性质
| 沸点 | 491.5±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.208±0.06 g/cm3(Predicted) |
Propargyl-PEG8-bromide 是一种 PROTAC 连接桥，属于 PEG 类。Propargyl-PEG8-bromide 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-bromide 是一种不可降解 (non-cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
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Non-cleavable
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PEGs
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PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.