β-Apo-13-carotenone
中文名称 | β-Apo-13-carotenone |
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中文同义词 | Β-APO-13-CAROTENONE |
英文名称 | β-Apo-13-carotenone |
英文同义词 | β-Apo-13-carotenone;D'Orenone;3,5,7-Octatrien-2-one, 6-methyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E,5E,7E)-;β-Apo-13-carotenone |
CAS号 | 17974-57-1 |
分子式 | C18H26O |
分子量 | 258.4 |
EINECS号 | |
相关类别 | |
Mol文件 | 17974-57-1.mol |
结构式 |
β-Apo-13-carotenone 性质
沸点 | 120 °C(Press: 0.0004 Torr) |
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密度 | 0.945±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:33.33 mg/mL (128.99 mM);水:< 0.1 mg/mL(不溶) |
β-apo-13-Carotenone is identified as enzymatic cleavage products of β-carotene in homogenates of intestinal mucosa of rat. β-apo-13-carotenone is found to antagonize the activation of RXRα by 9-cis-retinoic acid and is effective at concentrations as low as 1nM. Molecular modeling studies reveal that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα. β-apo-13-carotenone competes for 9cRA binding to RXRα with an affinity (7–8 nM) identical to 9cRA itself. β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003. β-apo-13-carotenone induces formation of the RXRα transcriptionally silent tetramer but does not inhibit coactivator recruitment to the isolated LBD. The uptake and/or metabolism of β-apo-13-carotenone does not allow for accumulation of these β-carotene metabolites in cells. 3T3-L1 adipocyte marker gene expression is induced by β-apo-carotenoid treatment.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-101953 | β-Apo-13-carotenone | 1 mg | 1818元 | |
2024/01/25 | HY-101953 | β-Apo-13-carotenone β-Apo-13-carotenone | 17974-57-1 | 5mg | 4000元 |