N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide
| 中文名称 | N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide |
|---|---|
| 中文同义词 | N-(2-氧代-2-((1,2,3,4-四氢萘-1-基)氨基)乙基)-[1,1'-联苯]-4-甲酰胺;化合物TAO KINASE INHIBITOR 1;CP 43,TAOK抑制剂 |
| 英文名称 | N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide |
| 英文同义词 | N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide;N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]-4-phenylbenzamide;CP 43;TAOK inhibitor 43;N-[2-Oxo-2-(1,2,3,4-tetrahydro-1-naphthalenylamino)ethyl]-4-biphenylcarboxamide;N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide;[1,1'-Biphenyl]-4-carboxamide, N-[2-oxo-2-[(1,2,3,4-tetrahydro-1-naphthalenyl)amino]ethyl]-;CP 43,TAO Kinase inhibitor-1,MAP kinase kinase kinase, MEKK, MAPKKK,CP43,CP-43,inhibit,TAO Kinase inhibitor 1,MAP3K,Inhibitor,TAO Kinase inhibitor1 |
| CAS号 | 850467-66-2 |
| 分子式 | C25H24N2O2 |
| 分子量 | 384.47 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 850467-66-2.mol |
| 结构式 | ![N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide 结构式](CAS/20180601/GIF/850467-66-2.gif) |
N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide 性质
| 沸点 | 673.2±54.0 °C(Predicted) |
|---|---|
| 密度 | 1.22±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100mM；乙醇：20 mM |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.08±0.46(Predicted) |
TAO Kinase inhibitor 1 (compound 43) 是一种选择性的、ATP 竞争性的 thousand-and-one amino acid kinases (TAOK) 抑制剂，针对 TAOK1 和 TAOK2 的 IC50s 分别为 11 nM 和 15 nM。TAO Kinase inhibitor 1 延迟有丝分裂以及诱导有丝分裂细胞死亡。
TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells.