| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037 |
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3bsc@sina.com |
| Products Intro: |
Product Name:CL 316243 disodiuM salt;5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]aMino]propyl]-1,3-benzodioxole-2,2-dicarboxylicaciddisodiuMsalt
CAS:151126-84-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
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sales@vdmbio.com |
| Products Intro: |
Product Name:CL 316243 disodiuM salt
CAS:151126-84-0
Purity:>=97%
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:CL 316243 disodium salt
CAS:151126-84-0
Purity:98% by HPLC Remarks:The sodium salt form of CL 316243, which has been found to be a β3-adrenoceptor agonist and could probably decrease blood insulin as well as glucose levels.
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| Company Name: |
Shanghai T&W Pharmaceutical Co., Ltd.
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| Tel: |
+86 21 61551611 |
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| Products Intro: |
Product Name:CL 316243 disodium salt
CAS:151126-84-0
Purity:98% Package:50kg;25kg;10kg;5kg;500g;500mg;
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| | 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Basic information |
| | 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Chemical Properties |
| storage temp. | Desiccate at -20°C | | solubility | H2O: >10 mg/mL | | form | solid | | color | white | | Water Solubility | Soluble to 100 mM in water | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| | 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Usage And Synthesis |
| Description | CL-316243 (151126-84-0) is a potent and selective β3-adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and decreases blood insulin and glucose levels.1?CL-316243 induces functionally active mitochondrial uncoupling protein (UCP) in white fat.2?Active?in vivo. | | Uses | CL 316243 Disodium Salt is a potent and highly selective β3-adrenoceptor agonist. | | Biological Activity | Potent and highly selective β 3 -adrenoceptor agonist (EC 50 = 3 nM); > 10000-fold selective over β 1 and β 2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo . | | in vitro | the compound was a potent stimulant of rat adipocyte lipolysis (β3 effect, ec50 = (3.0±0.3) x 10-8 m), had no effect on the rate of contraction of guinea pig atria (β1 effect, ec50 > 10-4 m), and had only a very limited ability to inhibit insulin-stimulated [14c] glucose incorporation into glycogen in isolated rat soleus muacle (β2 effect, ic50 = (3.0±1.0) x 10-5 m) [1]. | | in vivo | in rat, cl-316,243 treatment resulted in increased growth rates and significant changes in food consumption at the end of the 10-day treatment period. cl-316,243 treatment increased insulin responsiveness and sensitivity in non-insulin-resistant rodent species. the cl-316,243 induced increases in whole-body glucose disposal were due entirely to increases in adipose tissue glucose uptake, while muscle glucose uptake remained unaltered [2]. | | References | 1) Yoshida?et al. (1994),?Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific beta 3-adrenoceptor agonist in yellow KK mice; Life Sci.,?54?491
2) Yoshida?et al. (1998),?β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers; Am. J. Physiol.,?274?E469 |
| | 5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM Preparation Products And Raw materials |
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