CPD1599
| 中文名称 | CPD1599 |
|---|---|
| 中文同义词 | 化合物 T13602;化合物CDDO-2P-IM |
| 英文名称 | CDDO-3-P-Im |
| 英文同义词 | CDDO-3-P-Im;CPD1599;CPDB1599;CDDO-2P-Imidazolide;Oleana-1,9(11)-diene-2-carbonitrile, 3,12,28-trioxo-28-[4-(2-pyridinyl)-1H-imidazol-1-yl]- |
| CAS号 | 1883650-96-1 |
| 分子式 | C39H46N4O3 |
| 分子量 | 618.81 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1883650-96-1.mol |
| 结构式 |  |
CPD1599 性质
| 沸点 | 766.1±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（404.00 mM） |
| 酸度系数(pKa) | 1.60±0.19(Predicted) |
CDDO-2P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-2P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。
CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM.
CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC
50
of 5.8 nM.
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 30 nM, 100 nM |
| Incubation Time: | 4 days |
| Result: | Induced differentiation of U937 cells at 100 nM. |
CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
| Animal Model: | Seven week-old female A/J mice |
| Dosage: | 50 mg/kg, 200 mg/kg |
| Administration: | Diet; for 16 weeks |
| Result: | Decreased the number, the size and the severity of tumors. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-135953 | CDDO-3P-Im | 1 mg | 952元 | |
| 2024/01/25 | HY-135953 | CPD1599 CDDO-3P-Im | 1883650-96-1 | 5mg | 2500元 |