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| | 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Basic information |
| Product Name: | 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE | | Synonyms: | METHANONE, (4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)-;4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE;4-CHLORO-5'-FLUORO-2'-HYDROXYBENZOPHENONE;4'-Chloro-5-fluoro-2-hydroxybenzophenone97%;4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENON&;(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl) ketone;2-Hydroxy-4'-chloro-5-fluorobenzophenone;SL-79-182 | | CAS: | 62433-26-5 | | MF: | C13H8ClFO2 | | MW: | 250.65 | | EINECS: | 263-539-2 | | Product Categories: | C13 to C14;Carbonyl Compounds;Ketones | | Mol File: | 62433-26-5.mol |  |
| | 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Chemical Properties |
| Melting point | 65-69 °C(lit.) | | Boiling point | 145-152/5mm | | density | 1.376 | | Fp | 177℃ | | storage temp. | 2-8°C | | form | powder to crystal | | color | White to Yellow to Green | | Water Solubility | 8.999mg/L(37 ºC) | | CAS DataBase Reference | 62433-26-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2914500090 |
| | 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Usage And Synthesis |
| Uses | 4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin. | | Preparation | Preparation by Fries rearrangement of p-fluorophenyl p-chlorobenzoate,
? with titanium tetrachloride at 150° for 18 h (81%);
? with aluminium chloride, at 130° for 2 h (98%) or at 200° for 5 min or for 15 min (65%). |
| | 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE Preparation Products And Raw materials |
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