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ANHYDROTETRACYCLINE HYDROCHLORIDE

ANHYDROTETRACYCLINE HYDROCHLORIDE Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS:13803-65-1
Purity:0.99 Package:5KG;1KG
Company Name: Shandong chuangyingchemical Co., Ltd.
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Products Intro: Product Name:ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS:13803-65-1
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:Anhydrotetracycline hydrochloride
CAS:13803-65-1
Package:1 mL * 10mM (in DMSO);10 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS:13803-65-1
Purity:98% Package:1g;1.3USD
Company Name: Dideu Industries Group Limited
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Products Intro: Product Name:ANHYDROTETRACYCLINE HYDROCHLORIDE
CAS:13803-65-1
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
ANHYDROTETRACYCLINE HYDROCHLORIDE Basic information
Product Name:ANHYDROTETRACYCLINE HYDROCHLORIDE
Synonyms:ANHYDROTETRACYCLINE HYDROCHLORIDE;AnhydrotetracyclineHCl;Anhydrotetracycline hydrochloride, 'can be used as a secondary standard';2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, (4S,4aS,12aS)-;5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE;Anhydrotetracycline hydrochloride,'can be used as secondary standard.';Anhydrotetracycline hydrochloride ,97%;(4S,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDROCHLORIDE
CAS:13803-65-1
MF:C22H23ClN2O7
MW:462.88
EINECS:
Product Categories:Drug Analogues;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:13803-65-1.mol
ANHYDROTETRACYCLINE HYDROCHLORIDE Structure
ANHYDROTETRACYCLINE HYDROCHLORIDE Chemical Properties
Melting point 223 °C
RTECS QI7860000
storage temp. Refrigerator
solubility Soluble in ethanol, DMSO, or DMF
form Powder
color Yellow to bright yellow
Sensitive Moisture Sensitive
BRN 4228856
Stability:Hygroscopic
EPA Substance Registry System2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1)
Safety Information
Hazard Codes Xn
Risk Statements 63-36
Safety Statements 36/37/39-26
WGK Germany 3
HS Code 29413020
MSDS Information
ProviderLanguage
ACROS English
ANHYDROTETRACYCLINE HYDROCHLORIDE Usage And Synthesis
DescriptionThe tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.
Chemical Propertiesyellow to bright yellow powder
UsesAnhydrotetracycline is a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
UsesA Tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems.
UsesAnhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
ANHYDROTETRACYCLINE HYDROCHLORIDE Preparation Products And Raw materials
Preparation Products4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE
Tag:ANHYDROTETRACYCLINE HYDROCHLORIDE(13803-65-1) Related Product Information
2-ACETYL-1-TETRALONE 2-Hydroxy-2-methylpropiophenone Naphthalen-2-ethanol 2-Methyl-1-tetralone L-ISOLEUCINOL HCL 1,2-DIMETHYLNAPHTHALENE 1,3-DIMETHYLNAPHTHALENE C-(1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YL)-METHYLAMINE 5-METHOXY-1-TETRALONE 2,3-DIMETHYLNAPHTHALENE 1'-HYDROXY-2'-ACETONAPHTHONE ANHYDROTETRACYCLINE HYDROCHLORIDE 4-EPI-ANHYDROTETRACYCLINE HYDROCHLORIDE Tetracycline 5-Methylnaphthalene-1-ol 1-O-TOLYL-BUTANE-1,3-DIONE 3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE O-HYDROXYBENZOYLACETONE