β-淀粉样蛋白(31-35)

β-淀粉样蛋白(31-35)

中文名称β-淀粉样蛋白(31-35)
中文同义词异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸;AMYLOID Β肽(31-35);淀粉样肽 AMYLOID Β-PROTEIN (31-35)
英文名称H-ILE-ILE-GLY-LEU-MET-OH
英文同义词Isoleucinyl-isoleucinyl-glycinyl-leucinyl-methionine;AMyloid b-Protein (31-35);AMYLOID BETA-PROTEIN (31-35);AMYLOID-BETA PROTEIN (31-35), HUMAN, MOUSE, RAT;BETA-AMYLOID (31-35);IIGLM;ILE-ILE-GLY-LEU-MET;H-ILE-ILE-GLY-LEU-MET-OH
CAS号149385-65-9
分子式C25H47N5O6S
分子量545.74
EINECS号
相关类别多肽;目录多肽;peptide
Mol文件149385-65-9.mol
结构式β-淀粉样蛋白(31-35) 结构式

β-淀粉样蛋白(31-35) 性质

沸点866.4±65.0 °C(Predicted)
密度1.137±0.06 g/cm3(Predicted)
储存条件−20°C
溶解度溶于二甲基亚砜
酸度系数(pKa)3.24±0.10(Predicted)
形态固体
序列H-Ile-Ile-Gly-Leu-Met-OH

β-淀粉样蛋白(31-35) 用途与合成方法

β-Amyloid (31-35) 是具有神经毒性的天然 β 淀粉样肽的最短序列。

β-Amyloid (31-35) is a functional cytotoxic domain of Aβ peptide. β-Amyloid (31-35) increases the phosphorylation of biotinylated Aβ(1-40), enhances CDK-1 activity, and also inhibits binding of Aβ to cyclin B1. β-Amyloid (31-35) is cytotoxic, and such an effect can be inhibited by olomoucine in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons.
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 °C.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 °C. The sample was then centrifuged at 14000g for 10 min at 4-8 °C; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

多肽
β-淀粉样蛋白(31-35)由5个疏水性氨基酸组成的多肽片段,水溶性比较差。β-淀粉样蛋白(31-35)的合成工艺很特殊,因为五个氨基酸都是单保护氨基酸,所以可以选择2cl树脂进行合成,使用体积比TFA:DCM=2:98的溶液裂解就能得到目的粗品。
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-P1517异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸
β-Amyloid (31-35)
149385-65-91mg700元
2024/01/25HY-P1517异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸
β-Amyloid (31-35)
149385-65-95mg1400元

β-淀粉样蛋白(31-35) 上下游产品信息

"β-淀粉样蛋白(31-35)"相关产品信息
甘氨酰-L-谷氨酰胺一水合物 BETA-淀粉样蛋白片断25-35 BETA-AMYLOID(1-28) β-淀粉样蛋白(1-42),鼠 大豆肽 TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL Amyloidβ-Protein(3-42) β淀粉样蛋白(1-15) 淀粉-Β-蛋白片段12-28 β-Amyloid(35-42) GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU β-Amyloid(12-20) β-Amyloid(10-35),amide ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU BETA-AMYLOID(1-38) PHE-ARG-HIS-ASP-SER-GLY-TYR ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU
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