DS-437
中文名称 | DS-437 |
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中文同义词 | 化合物 T15169 |
英文名称 | DS-437 |
英文同义词 | DS-437;DS-437 (DS437;Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-;DS-437 >=98% (HPLC) |
CAS号 | 1674364-87-4 |
分子式 | C15H23N7O4S |
分子量 | 397.45 |
EINECS号 | |
相关类别 | |
Mol文件 | 1674364-87-4.mol |
结构式 |
DS-437 性质
密度 | 1.71±0.1 g/cm3(Predicted) |
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储存条件 | 2-8°C |
溶解度 | DMSO:125.0(最大浓度 mg/mL);314.5(最大浓度 mM) |
酸度系数(pKa) | 13.13±0.70(Predicted) |
形态 | 粉末 |
颜色 | 白色至米色 |
DS-437 was able to inhibit methylation of an H4[1–24] peptide by the PRMT5–MEP50 complex under balanced conditions (cofactor and substrate concentrations set at their respective Km values) in a dose-dependent manner with an IC50 of 5.9 ± 1.4 μM.
DS-437 increased total CD8
+
and CD8
+
PD-1
+
T cells.
DS-437 (10 mg/kg; i.p.; 5 times a week) has some beneficial effects on inhibiting tumor growth. The combination of DS-437 and the anti-p185 erbB2/neu antibody 4D5 had even more dramatic effects.
Animal Model: | Six to Ten weeks old female Balb/c mice (bearing CT26Her2 tumor cells) |
Dosage: | 10 mg/kg |
Administration: | i.p.; 5 times a week |
Result: | Had some beneficial effects on inhibiting tumor growth. |
安全信息
危险品运输编号 | UN 2811 6.1 / PGIII |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-124131 | DS-437 DS-437 | 1674364-87-4 | 5mg | 800元 |
2024/08/19 | HY-124131 | DS-437 DS-437 | 1674364-87-4 | 10mM * 1mLin DMSO | 880元 |