TH1020
中文名称 | TH1020 |
---|---|
中文同义词 | 4-((4-苄基-5-(吡啶-4-基)-4H-1,2,4-三唑-3-基)硫基)吡啶并[3',2':4,5]噻吩并[3,2-D]嘧啶;化合物TH1020;4-((4-苄基-5-(吡啶-4-基)-4H-1,2,4-三唑-3-基)硫基)吡啶并[3',2':4,5]噻吩并[3,2-D]嘧啶;TH 1020,TOLL样受体(TLR)5 / FLAGELLIN复合拮抗剂 |
英文名称 | TH1020 |
英文同义词 | TH1020;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2';TH1020 >=95% (HPLC);4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine;interaction,inhibit,Bacterial,flagellin,TH-1020,TH1020,Toll-like Receptor (TLR),TLR5,protein-protein,TNF-α,Inhibitor,TH 1020;Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-;4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine |
CAS号 | 1841460-82-9 |
分子式 | C23H15N7S2 |
分子量 | 453.54 |
EINECS号 | |
相关类别 | |
Mol文件 | 1841460-82-9.mol |
结构式 |
TH1020 性质
沸点 | 765.8±70.0 °C(Predicted) |
---|---|
密度 | 1.51±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 氯仿:1mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 1.92±0.10(Predicted) |
颜色 | 白色至米色 |
IC50: 0.85 μM (toll-like receptor 5 (TLR5)/flagellin complex)
TH1020 inhibits the downstream signaling transduction mediated by the formation of the TLR5/Flagellin complex. TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 almost completely abolishes the TLR5-mediated TNF-α secretion at 0.37 μM.
The IL-17C secretion is almost completely abolished by TH1020 (0.5 μM) in bacterial strain C83901 infected IPEC-J2 cells.
Blocking TLR5 with TH1020 (0.5 μM) dramatically inhibits porcine beta-defensin (pBD)-2, claudin-1 and -2 mRNA expression in C83091 infected IPEC-J2 cells.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-116961 | TH1020 | 1 mg | 363元 | |
2024/08/19 | HY-116961 | TH1020 TH1020 | 1841460-82-9 | 5mg | 800元 |