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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Basic information
Product Name:(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
Synonyms:SPIRADOLINE MESYLATE;U-62066;(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE;U-62066 (mesylate);rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide,monomethanesulfonate
CAS:87173-97-5
MF:C23H34Cl2N2O5S
MW:521.49
EINECS:
Product Categories:
Mol File:87173-97-5.mol
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Structure
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Chemical Properties
storage temp. 2-8°C
solubility H2O: 14 mg/mL
form solid
color white
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Usage And Synthesis
UsesAnalgesic.
in vivo

Spiradoline mesylate (U-62066; 0.1-0.4 mg/kg; subcutaneous injection; once; Sprague-Dawley rats) treatment dose-dependently reduces social behaviors in non-stressed adults, producing social avoidance at the highest dose tested, while younger animals displays reduced sensitivity to this socially suppressing effect of Spiradoline mesylate. In stressed animals, the socially suppressing effects of the Spiradoline mesylate are blunted at all ages, with juveniles and adolescents exhibiting increased social preference in response to certain doses of U-62066[1].

Animal Model:Juvenile, adolescent and adult Sprague-Dawley male and female rats exposured to repeated restraint[1]
Dosage:0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg, and 0.4?mg/kg
Administration:Subcutaneous injection; once
Result:Dose-dependently reduced social behaviors in non-stressed adults, producing social avoidance at the highest dose tested.
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Preparation Products And Raw materials
Tag:(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE(87173-97-5) Related Product Information
(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine 1,2-Diaminocyclohexane (1R,2R)-(-)-1,2-Diaminocyclohexane (R)-(+)-1,2-Diaminopropane dihydrochloride 4-Methylcyclohexyl amine trans-4-Aminocyclohexanol hydrochloride trans-4-(Dimethylamino)cyclohexanol 4-ACETAMIDOCYCLOHEXANOL N,N'-Dimethyl-1,2-cyclohexanediamine (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE 1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) N-(2-phenylethyl)cyclohexanamine TRANS-(1R,2R)-N,N'-BISMETHYL-1,2-CYCLOHEXANEDIAMINE HCL (2R,3R)-(+)-2,3-BUTANEDIAMINE DIHYDROCHLORIDE CHEMBRDG-BB 4024898 TRANS-4-(METHYLAMINO)CYCLOHEXANOL (3,4-DICHLOROPHENYL)ACETALDEHYDE CHEMBRDG-BB 4018237
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