CGS 15435
| 中文名称 | CGS 15435 |
|---|---|
| 中文同义词 | 化合物 T10783;化合物CGS 15435 |
| 英文名称 | CGS 15435 |
| 英文同义词 | CGS 15435;1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)- |
| CAS号 | 95853-92-2 |
| 分子式 | C20H21ClN2O2 |
| 分子量 | 356.85 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 95853-92-2.mol |
| 结构式 |  |
CGS 15435 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
|
TXA 2 1 nM (IC 50 ) |
CGS 15435 is a highly specific Tx synthetase inhibitor. CGS 15435 is only weakly effective as an inhibitor of PGE 2 (Cyclooxygenase, IC 50 =1200 μM), prostacyclin (PGI 2 synthetase, IC 50 =90 μM) or 5-Lipoxygenase (IC 50 =60 μM) product formation.
CGS 15435 has a long duration of action, since the increases in the plasma levels of TxB 2 are prevented even at 24 h after CGS 15435 administration. CGS 15435 significantly inhibits TxB 2 formation 4, 6, 12 and 24 h after dosing. Administration of CGS 15435 0.25 or 24 h prior to Arachidonic acid (AA) produced no increase in TxB 2 in the surviving animals (4/4 and 5/6, respectively). The final TxB 2 levels in the CGS15435A (0.25 and 24 h pretreatment) groups are significantly lower (P<0.05) than those seen in the AA or the Dazoxiben (2 h pretreatment) groups.