阿托西班
| 中文名称 | 阿托西班 |
|---|---|
| 中文同义词 | 阿托西班;阿托西班杂质;阿托西班杂质 1;醋酸阿托西班 90779-69-4;醋酸阿托西班 ATOSIBANACETATE;阿托西班,醋酸阿托西班;醋酸阿托西班原料;阿托西班-多肽原料委托生产 |
| 英文名称 | Atosiban |
| 英文同义词 | 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin;oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l;rwj22164;1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin;[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2;(2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide;1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin;1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin |
| CAS号 | 90779-69-4 |
| 分子式 | C43H67N11O12S2 |
| 分子量 | 994.19 |
| EINECS号 | 806-815-5 |
| 相关类别 | 多肽;中间体;湖北厂家;阿托西班;康宝泰;多肽中间体;医药原料药;生物制药;生化试剂;多肽原料药;原料药;医药原料;医用原料;肠胃泌尿生殖系统类;药物多肽;Peptide;hormones;定制多肽;库存;对照品-杂质对照品;标准品;原料药;生物化工;化学试剂 |
| Mol文件 | 90779-69-4.mol |
| 结构式 |  |
阿托西班 性质
| 熔点 | >165oC (dec.) |
|---|---|
| 沸点 | 1469.0±65.0 °C(Predicted) |
| 密度 | 1.254±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | H2O:≤100 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.81±0.70(Predicted) |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble to 50 mg/ml in water |
| CAS 数据库 | 90779-69-4(CAS DataBase Reference) |
醋酸阿托西班是由9个氨基酸组成的二硫键型的环状多肽，是1，2，4和8位修饰的缩宫素分子，肽的N端为3-巯基丙酸(巯基与[Cys]6的巯基形成二硫键)，C端为酰胺的形式，N端第二氨基酸是乙基化修饰的[D-Tyr(Et)]2，醋酸阿托西班在药品中以醋酸盐的形式存在，通用名为醋酸阿托西班。
Atosiban inhibits the oxytocin-mediated release of IP3 from the myometrial cell membrane. There is reduced release of intracellular, stored calcium from the sacroplasmic reticulum of myometrial cells, and reduced influx of Ca 2+ from the extracellular space through voltage gated channels. In addition, Atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua.
The posterior pituitary hormones, oxytocin and arginine vasopressin, differ in structure by only two amino acids, and Atosiban influences physiological effects of arginine vasopressin on the feto-maternal cardiovascular and renal systems. In late-gestation sheep, the administration of Atosiban for 1 hour fails to induce fetomaternal cardiovascular changes.
Atosiban blocks the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | RS7590000 |
| 海关编码 | 2934999090 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-17572A | 阿托西班 Atosiban acetate | 90779-69-4 | 5mg | 700元 |
| 2024/01/25 | HY-17572A | 阿托西班 Atosiban acetate | 90779-69-4 | 10mg | 1000元 |