化合物 T16773
| 中文名称 | 化合物 T16773 |
|---|---|
| 中文同义词 | 化合物 T16773;2'-(4-氨基苯基)-1H,3'H-[2,5'-联苯并[D]咪唑]-5-胺;化合物RO 90-7501;RO 90-7501,AΒ42原纤维形成的抑制剂;2'-(4-氨基苯基)-[2,5'-bi-1H-苯并咪唑] -5-胺 |
| 英文名称 | Ro 90-7501 |
| 英文同义词 | 2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine;RO90-7501; RO 907501;2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine;2,5'-Bi-1H-benzimidazol]-5-amine, 2'-(4-aminophenyl)- |
| CAS号 | 293762-45-5 |
| 分子式 | C20H16N6 |
| 分子量 | 340.388 |
| EINECS号 | |
| 相关类别 | 标准品 |
| Mol文件 | 293762-45-5.mol |
| 结构式 |  |
化合物 T16773 性质
| 储存条件 | Store at +4°C |
|---|---|
| 溶解度 | 二甲基亚砜：20 毫克/毫升 |
| 形态 | 固体 |
| 颜色 | 棕色 |
|
Amyloid β42
|
ATM
|
Protein phosphatase 5
|
Apoptosis
|
Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells. Ro 90-7501 significantly increases apoptosis and impaired cell cycle after irradiation. Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.
RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C.
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume.
| Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation |
| Dosage: | 5 μg/g |
| Administration: | Intraperitoneal injection; daily; for 21 days |
| Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-103241 | 化合物 T16773 Ro 90-7501 | 293762-45-5 | 1 mg | 371元 |
| 2026/09/15 | HY-103241 | 化合物 T16773 Ro 90-7501 | 293762-45-5 | 5 mg | 850元 |