富马酸单甲酯
中文名称 | 富马酸单甲酯 |
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中文同义词 | 富马酸单甲酯;富马酸单甲酯, 97%+;富马酸单甲基酯;富马酸单甲酯 5G;富马酸单甲酯-D3;(E)-4-甲氧基-4-氧代丁基-2-烯酸;富马酸单甲酯 标准品;富马酸单甲酯(CAS号:2756-87-8) |
英文名称 | Monomethyl fumarate |
英文同义词 | (E)-2-Butenedioic acid hydrogen 1-methyl ester;Fumaric acid hydrogen 1-methyl ester;Monomethyl trans-ethylene-1,2-dicarboxylate;Monomethyl fumarate;mono-Methyl fumarate,Fumaric acid monomethyl ester, Methyl hydrogen fumarate;(2E)-4-Methoxy-4-oxobut-2-enoic acid;(2E)-2-Butenedioic Acid 1-Methyl Ester;(E)-2-Butenedioic Acid MonoMethyl Ester |
CAS号 | 2756-87-8 |
分子式 | C5H6O4 |
分子量 | 130.1 |
EINECS号 | 220-412-6 |
相关类别 | 羰基化合物;酯;杂质对照品;原料;食品添加剂;杀菌防腐剂;防腐剂;有机中间体;有机化工原料;化工原料;其他原料;化工材料;助剂;有机化工 |
Mol文件 | 2756-87-8.mol |
结构式 |
富马酸单甲酯 性质
熔点 | 144-145 °C (lit.) |
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沸点 | 250.0±23.0 °C(Predicted) |
密度 | 1.37 g/cm3 |
储存条件 | 2-8°C |
溶解度 | 可溶于氯仿(少许)、DMSO(少许)、甲醇(少许) |
酸度系数(pKa) | 3.40±0.10(Predicted) |
形态 | 固体 |
颜色 | 米白色 |
最大波长(λmax) | 209nm(MeOH)(lit.) |
CAS 数据库 | 2756-87-8(CAS DataBase Reference) |
Target | Value |
GPR109A
() |
Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC
50
of 70 nM. Monomethyl fumarate induces a dose-dependent Ca
2+
signal in GPR109A transfected cells with an EC
50
of 9.4 μM.
Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.
A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α.
Animal Model: | Albino BALB/c mice (male, 6 weeks old) |
Dosage: | 50, 65, 75, 100 mg/kg |
Administration: | IP |
Result: | Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. |