42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin

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Products Intro: Product Name:Rapamycin Impurity 32
CAS:143030-02-8
Purity:>95.0% Package:10mg/RMB 2500
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Products Intro: Product Name:everolimus
CAS:143030-02-8
Purity:95% HPLC Package:50mg 100mg
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Products Intro: Product Name:Rapamycin Impurity 32
CAS:143030-02-8
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Products Intro: Product Name:42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
CAS:143030-02-8
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Products Intro: CAS:143030-02-8
Purity:95%,98% HPLC Package:5G;1G
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Basic information
Product Name:42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
Synonyms:42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin;Rapamycin Impurity 32;Rapamycin, 42-O-[(1,1-dimethylethyl)dimethylsilyl]-;Clobetasone Butyrate Impurity 9 (Clobetasone Butyrate EP Impurity I);Rapamycin Impurity 21
CAS:143030-02-8
MF:C57H93NO13Si
MW:1028.45
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Mol File:143030-02-8.mol
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Structure
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Chemical Properties
Boiling point 977.0±75.0 °C(Predicted)
density 1.12±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Dichloromethane, Methanol
form Solid
pka10.40±0.70(Predicted)
color White
Safety Information
MSDS Information
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Usage And Synthesis
Uses42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin is an intermediate in the synthesis of 8-O-Methyl-rapamycin which is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Preparation Products And Raw materials
Tag:42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin(143030-02-8) Related Product Information
Everolimus 2-Piperidinecarboxylic acid, 1-[[(2R,3R,6S)-6-[(2S,3E,5E,7E,9S,11R)-2,13-dimethoxy-3,9,11-trimethyl-12-oxo-3,5,7-tridecatrienyl]tetrahydro-2-hydroxy-3-methyl-2H-pyran-2-yl]oxoacetyl]-, (1S,4R,5E)-1-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-4,6-dimethyl-3,7-dioxo-5-heptenyl es... Everolimus EP Impurity E USDOYNAPNXMXOE-SPSCNLKESA-N Everolimus Impurity 1 23,27-Epoxy(7E,15E,17E,19E)-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexam... Everolimus Related Compound 3 EveroliMus-d4 Everolimus Related Compound 2 Rapamycin, 32-O-demethyl- Seco Rapamycin Everolimus Hydrolized Impurity 28-epirapamycin Everolimus Ring-Opening Impurity 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone