CROMAKALIM

CROMAKALIM Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:(±)-Cromakalim
CAS:94470-67-4
Purity:0.99 Package:5KG;1KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Cromakalim;BRL34915;(±)-Cromakalim;BRL 34915;BRL-34915
CAS:94470-67-4
Package:10 mg;25 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:(+/-)-CroMakaliM
CAS:94470-67-4
Package:250Mg,25Mg
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:CroMakaliM;trans-3,4-dihydro-3-hydroxy-2,2-diMethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile
CAS:94470-67-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:(+/-)-CroMakaliM
CAS:94470-67-4
Purity:98%
CROMAKALIM Basic information
Product Name:CROMAKALIM
Synonyms:Cromakalim=([+/-]-trans-6-Cyano-3,4-dihydro-2,2-;(+/-)-CROMAKALIM;CROMAKALIM;TRANS-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE;(+/-)-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-(2-OXOPYRROLIDIN-1-YL)-2H-1-BENZOPYRAN-3-OL;[+/-]-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-[2-OXOPYRROLIDIN-1-YL]-2H-1-BENZOPYRAN-3-OL;BRL-34915;rac-(3α*,4β*)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)-2H-1-benzopyran-6-carbonitrile
CAS:94470-67-4
MF:C16H18N2O3
MW:286.33
EINECS:
Product Categories:All Inhibitors;Inhibitors
Mol File:94470-67-4.mol
CROMAKALIM Structure
CROMAKALIM Chemical Properties
Melting point 242-244°C
storage temp. 2-8°C
solubility Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
form solid
color Off-white
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
CROMAKALIM Usage And Synthesis
Description(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 μM) and cardioprotective (IC50 = 0.03 μM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance.
Chemical PropertiesWhite Crystalline Solid
UsesCromakalim has been used:
  • as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
  • as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
  • as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

UsesCromakalim causes vasodilation by activation of potassim channels
DefinitionChEBI: Cromakalim is a 1-benzopyran.
Biological ActivityPrototypical K ATP channel opener. Relaxes rabbit isolated portal vein with an IC 50 value of 21 nM . Potent, orally active and hypotensive in vivo .
Biochem/physiol ActionsCromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.
References1) Sanguinetti?et al. (1988),?BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle; Proc. Natl. Acad. Sci. USA,?85?8360 2) Wu?et al.?(2011),?Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord; Pain,?152?2605 3) Roy Chowdhury?et al.?(2017),?ATP sensitive potassium channel openers: A new class of ocular hypotensive agents; Exp. Eye Res.,?158?85 4) Cao?et al.?(2016),?Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord; Clin. J. Pain,?32?617
CROMAKALIM Preparation Products And Raw materials
Tag:CROMAKALIM(94470-67-4) Related Product Information
3-M-TOLYL-DL-BETA-ALANINOL (S)-3-(1-Aminoethyl)benzonitrile 3-(methylaminomethyl)benzonitrile Anisonitrile 4-ETHOXYBENZONITRILE 4-TERT-BUTOXYBENZONITRILE (R)-3-(1-aminoethyl)benzonitrile (S)-3-Amino-3-phenylpropan-1-ol LEVCROMAKALIM (S)-1-(2-Methoxyphenyl)ethylamine 3-CYANOBENZYLAMINE CROMAKALIM CHROMAN-4-YLAMINE (S)-3-Dimethylamino-3-phenylpropanol 3-(Diethylamino)-1,2-propanediol N-(2-Hydroxyethyl)-2-pyrrolidone 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE 4-isopropoxybenzonitrile