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楝酰胺

楝酰胺 更多供应商
公司名称: 海南梵圣生物科技有限公司  黄金产品
联系电话: 17771897798
产品介绍: 中文名称:楝酰胺
英文名称:RocaglaMide
CAS:84573-16-0
纯度:0.98 包装信息:10g;25g;100g;500g;1kg
公司名称: 上海佰世凯化学科技有限公司  
联系电话: 021-20908456
产品介绍: 英文名称:RocaglaMide
CAS:84573-16-0
备注:C11954
公司名称: BOC Sciences  
联系电话: 16314854226
产品介绍: 英文名称:Rocaglamide
CAS:84573-16-0
纯度:95% 包装信息:$499/1mg 备注:Rocaglamide is the first cyclopenta[b]benzofuran derivative extracted from Aglaia elliptifolia in 1982 by King and colleagues. Its IC50 value is ~50 nM for the heat shock reporter. It has antileukemic
公司名称: 云南西力生物技术股份有限公司  
联系电话: 0871-65217109
产品介绍: 中文名称:楝酰胺
英文名称:Rocaglamide
CAS:84573-16-0
纯度:97.5% 包装信息:5mg 备注:BBP00609
公司名称: 上海皓元医药股份有限公司  
联系电话: 86-21-58998985
产品介绍: 英文名称:Rocaglamide
CAS:84573-16-0
纯度:>98% 包装信息:1100RMB/200ug 备注:试剂级
楝酰胺生产厂家及价格列表
Rocaglamide_上海博湖生物科技有限公司
价格:询价
2021/03/30 12:42:02
楝酰胺
生物活性靶点体外研究体内研究
中文名称:楝酰胺
中文同义词:洛克米兰酰胺;楝酰胺;(1R,2R,3S,3AR,8BS)-1,8B-二羟基-6,8-二甲氧基-3A-(4-甲氧基苯基)-N,N-二甲基-3-苯基-2,3,3A,8B-四氢-1H-环戊二烯并[B]苯并呋喃-2-甲酰胺
英文名称:ROCAGLAMIDE
英文同义词:ROCAGLAMIDE;(1R)-2,3,3a,8b-Tetrahydro-1α,8bβ-dihydroxy-6,8-dimethoxy-3aβ-(4-methoxyphenyl)-N,N-dimethyl-3β-phenyl-1H-cyclopenta[b]benzofuran-2α-carboxamide;(1R)-N,N-Dimethyl-1α,8bβ-dihydroxy-3β-phenyl-3aβ-(4-methoxyphenyl)-6,8-dimethoxy-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2α-carboxamide;2,3,3a,8b-Tetrahydro-1α,8bβ-dihydroxy-6,8-dimethoxy-3aβ-(4-methoxyphenyl)-N,N-dimethyl-3β-phenyl-1H-cyclopenta[b]benzofuran-2α-carboxamide;2,3,3a,8b-Tetrahydro-N,N-dimethyl-1α,8bβ-dihydroxy-6,8-dimethoxy-3β-phenyl-3aβ-(4-methoxyphenyl)-1H-cyclopenta[b]benzofuran-2α-carboxamide;N,N-Dimethyl-1α,8bβ-dihydroxy-6,8-dimethoxy-3β-phenyl-3aβ-(4-methoxyphenyl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2α-carboxamide;(1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide;NSC 326408
CAS号:84573-16-0
分子式:C29H31NO7
分子量:505.56
EINECS号:
相关类别:生物碱
Mol文件:84573-16-0.mol
楝酰胺
楝酰胺 性质
熔点 117-118 °C
沸点 667.3±55.0 °C(Predicted)
密度 1.321±0.06 g/cm3(Predicted)
储存条件 ?20°C
形态film
酸度系数(pKa)11.70±0.70(Predicted)
颜色colorless
楝酰胺 用途与合成方法
生物活性Rocaglamide (Roc-A) 是从 Aglaia 中分离出来,可用于咳嗽,受伤,哮喘和炎症性皮肤病。Rocaglamide 是 T 细胞中一种有效的 NF-κB 活化抑制剂。Rocaglamide 是一种有效的选择性热休克因子 1 (HSF1) 活化抑制剂,IC50 约为 50 nM。Rocaglamide 还抑制翻译起始因子 eIF4A 的功能。Rocaglamide 还具有抗癌特性。
靶点

HSF1

50 nM (IC 50 )

体外研究

Rocaglamide enhances TRAIL-induced apoptosis in resistant HCC cells. Treatment with Rocaglamide alone leads to apoptosis in 9% HepG2 and 11% Huh-7 cells and treatment with TRAIL induces apoptosis in 16% HepG2 and 17% Huh-7 cells. However, the combination of Rocaglamide and TRAIL induces apoptosis in 55% HepG2 and 57% Huh-7 cells, which is evidently more than an additive effect. A similar result is obtained by measurement of cell viability using crystal violet staining. Rocaglamide has the potential to sensitize highly chemoresistant HepG2 and Huh-7 cells to TRAIL-based therapy.

体内研究

Tumor volumes in the Rocaglamide-treated group are 45±12% compared with the control group. Rocaglamide significantly suppresses tumor growth compared with that in the control group. Treatment with Rocaglamide does not lead to any reduction in body weight and no apparent signs of toxicity are observed in the mice during the treatment, suggesting that Rocaglamide is generally tolerated well.

安全信息
WGK Germany 3
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