氯苄哌醚联苯酰苯酸盐

氯苄哌醚联苯酰苯酸盐

中文名称氯苄哌醚联苯酰苯酸盐
中文同义词氯苄哌醚联苯酰苯酸盐;氯哌斯汀芬地柞酸盐;氯哌斯汀芬地柞酸;氯哌酮芬地唑;1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐;化合物 T13619
英文名称o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
英文同义词o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1);Cloperastine fendizoate;Levocloperastine Fendizoate;Cloperastine Febdizoate;o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1);1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate;Levocloperastine Fendizoate Racemic Impurity;1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
CAS号85187-37-7
分子式C40H38ClNO5
分子量648.2
EINECS号286-126-9
相关类别医药原料
Mol文件85187-37-7.mol
结构式氯苄哌醚联苯酰苯酸盐 结构式

氯苄哌醚联苯酰苯酸盐 性质

熔点185-187°C
储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可溶于DMSO(少许)、甲醇(少许)
形态固体
颜色白色至类白色
稳定性吸湿性

氯苄哌醚联苯酰苯酸盐 用途与合成方法

Cloperastine fendizoate 抑制 hERG K+ 电流,IC50 为 27 nM,这种作用具有浓度依赖性。

27 nM (K + currents)

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with IC 50 value of 27±3 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-B2179氯苄哌醚联苯酰苯酸盐
Cloperastine fendizoate
85187-37-7500mg500元
2024/01/25HY-B2179氯苄哌醚联苯酰苯酸盐
Cloperastine fendizoate
85187-37-710mM * 1mLin DMSO550元

氯苄哌醚联苯酰苯酸盐 上下游产品信息

"氯苄哌醚联苯酰苯酸盐"相关产品信息
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