| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Glisoxepid
CAS:25046-79-1
Package:100Mg,10Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:Glisoxepid
CAS:25046-79-1
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | glisoxepide Basic information |
| | glisoxepide Chemical Properties |
| Melting point | 189° | | density | 1.2348 (rough estimate) | | refractive index | 1.6460 (estimate) | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) | | form | Solid | | pka | 5.92±0.10(Predicted) | | color | Pale Yellow to Yellow |
| Toxicity | LD50 in mice, rats, cats, dogs (g/kg): >10.0, >10.0, >4.0, >2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn) |
| | glisoxepide Usage And Synthesis |
| Originator | Pro-Diaban,Bayer,W. Germany,1974 | | Uses | Labelled Glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2. | | Definition | ChEBI: Glisoxepide is a sulfonamide. | | Manufacturing Process | There is obtained from 4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]-
benzene-sulfonamide (prepared from 5-methyl-isoxazole-(3)-carboxylic acid
chloride and 4-(β-aminoethyl)benzene-sulfonamide hydrochloride, MP 213° to
214°C in pyridine) and chloroformic acid methyl ester, in a yield of 69%, the
compound N-[[-4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]]-benzenesulfonyl]]-methyl-urethane in the form of colorless crystals of MP 173°C.
From the sulfonyl-urethane described above and N-amino-hexamethyleneimine, there is obtained, in a yield of 70%. the compound 4-[[4-[β-[5-methylisoxazolyl-(3)-carboxamido]-ethyl]-benzene-sulfonyl]]-1,1-hexamethylenesemicarbazide in the form of colorless crystals of MP 189°C. | | Therapeutic Function | Oral hypoglycemic |
| | glisoxepide Preparation Products And Raw materials |
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